Site Specific and Global Epigenomic Editing

In recent years, alongside the largely popularized advances in human genome editing and CRISPR-cas9-driven therapeutics, epigenomic editing has made strong strides, though a clear understanding is still forming in the field of the exact role that epigenetics play in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. Key questions for researchers embarking in this field include: Which of the hundreds of epigenomic marks and features are relevant, and which of those are likely to serve a role in regulating gene expression, cell behavior, and phenotypic outcomes? This volume is the first to provide a thorough, conceptual introduction to the field of epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Protocols, and applied case studies examine early disease targets and likely pathways of therapeutic significance, while also outlining common challenges in the field, and the addressing the range of bioethical questions that come with altering phenotypes. This book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research. Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery Discusses fundamental theory, experimental design, and applied approaches alongside common research challenges and bioethical concerns Examines epigenomic editing's potential role in modulation of developmental, neuropsychiatric, and immunological disorders, as well as viral infections and cancer

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  • Author : Feng C Zhou
  • Publisher : Academic Press
  • Pages : 704 pages
  • ISBN : 9780128193983
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKSite Specific and Global Epigenomic Editing

Site Specific and Global Epigenomic Editing

Site Specific and Global Epigenomic Editing
  • Author : Feng C Zhou
  • Publisher : Academic Press
  • Release : 15 June 2022
GET THIS BOOKSite Specific and Global Epigenomic Editing

In recent years, alongside the largely popularized advances in human genome editing and CRISPR-cas9-driven therapeutics, epigenomic editing has made strong strides, though a clear understanding is still forming in the field of the exact role that epigenetics play in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. Key questions for researchers embarking in this field include: Which of the hundreds of epigenomic marks and features are

Chromatin and Epigenetics

Chromatin and Epigenetics
  • Author : Colin Logie,Tobias Aurelius Knoch
  • Publisher : BoD – Books on Demand
  • Release : 29 January 2020
GET THIS BOOKChromatin and Epigenetics

Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D

Epigenome Editing

Epigenome Editing
  • Author : Albert Jeltsch,Marianne G. Rots
  • Publisher : Humana Press
  • Release : 10 March 2018
GET THIS BOOKEpigenome Editing

This detailed book explores the concepts and applications of epigenome editing, as presented by leading scientists in the field. Beginning with some general and topical reviews, the collection continues by covering the design of DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step,

Targeted Genome Editing Using Site-Specific Nucleases

Targeted Genome Editing Using Site-Specific Nucleases
  • Author : Takashi Yamamoto
  • Publisher : Springer
  • Release : 05 January 2015
GET THIS BOOKTargeted Genome Editing Using Site-Specific Nucleases

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease
  • Author : Cheryl S Rosenfeld
  • Publisher : Academic Press
  • Release : 10 October 2015
GET THIS BOOKThe Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
  • Author : Shuai Li,John Hopper
  • Publisher : Academic Press
  • Release : 31 August 2021
GET THIS BOOKTwin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
  • Author : Suming Huang,Michael D Litt,C. Ann Blakey
  • Publisher : Academic Press
  • Release : 19 October 2015
GET THIS BOOKEpigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
  • Author : José Luis García-Giménez
  • Publisher : Academic Press
  • Release : 07 December 2015
GET THIS BOOKEpigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e.

The Epigenetics Revolution

The Epigenetics Revolution
  • Author : Nessa Carey
  • Publisher : Columbia University Press
  • Release : 06 March 2012
GET THIS BOOKThe Epigenetics Revolution

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the

Epigenetics Methods

Epigenetics Methods
  • Author : Trygve Tollefsbol
  • Publisher : Academic Press
  • Release : 08 July 2020
GET THIS BOOKEpigenetics Methods

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used

CRISPR Genome Surgery in Stem Cells and Disease Tissues

CRISPR Genome Surgery in Stem Cells and Disease Tissues
  • Author : Stephen H. Tsang
  • Publisher : Academic Press
  • Release : 20 October 2021
GET THIS BOOKCRISPR Genome Surgery in Stem Cells and Disease Tissues

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in

CRISPR and RNAi Systems

CRISPR and RNAi Systems
  • Author : Kamel A. Abd-Elsalam,Ki-Taek Lim
  • Publisher : Elsevier
  • Release : 27 February 2021
GET THIS BOOKCRISPR and RNAi Systems

Plants are vulnerable to pathogens including fungi, bacteria, and viruses, which cause critical problems and deficits. Crop protection by plant breeding delivers a promising solution with no obvious effect on human health or the local ecosystem. Crop improvement has been the most powerful approach for producing unique crop cultivars since domestication occurred, making possible the main innovations in feeding the globe and community development. Genome editing is one of the genetic devices that can be implemented, and disease resistance is

Quantitative Genetics, Genomics and Plant Breeding, 2nd Edition

Quantitative Genetics, Genomics and Plant Breeding, 2nd Edition
  • Author : Manjit S. Kang
  • Publisher : CABI
  • Release : 01 April 2020
GET THIS BOOKQuantitative Genetics, Genomics and Plant Breeding, 2nd Edition

This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize,

Mechanisms of DNA Methylation Control and Epigenome Engineering

Mechanisms of DNA Methylation Control and Epigenome Engineering
  • Author : Wanlu Liu
  • Publisher : Unknown Publisher
  • Release : 01 July 2022
GET THIS BOOKMechanisms of DNA Methylation Control and Epigenome Engineering

Cytosine DNA methylation is an evolutionarily conserved epigenetic mark that plays critical roles in diverse biological processes, including gene and transposon silencing and imprinting. In mammals, DNA methylation mostly occurs in the symmetric dinucleotide CG sites. In the model plant Arabidopsis thaliana, DNA methylation frequently occurs at cytosine bases in all sequence contexts (CG, CHG and CHH, where H represents A, C or T). In Arabidopsis, de novo DNA methylation is established by a process known as RNA-directed DNA methylation (