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Sox2: Biology and Role in Development and Disease offers a thorough discussion of the important role of Sox2 in cellular and developmental processes, aimed at facilitating greater understanding of how Sox2 functions across different disciplines. The book discusses the basic biology of Sox2 to help establish the critical foundational knowledge necessary for deeper molecular and functional analysis. The book also provides insight into how the Sox2 transcription factor plays a key role in pluripotency induction, maintenance, and development. Helpful as
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Accompanying CD-ROM (in v. 2) has image collections which can be saved in PowerPoint or HTML.
The transcription factor Sox2 (SRY-related HMG box gene 2) plays a pivotal role in maintaining self-renewal and pluripotency in embryonic stem (ES) cells derived from the inner cell mass (ICM) of the embryo Previously it was shown that Sox2-/- mouse embryos die soon after implantation, ' how materna! Sox2" transcripts may mask an eariier phenotype. This study has shown that siRNA knock-down of Sox2 at the 2-cell stage of the preimplantation mouse embryo results in embryo arrest at the
Mots-clés de l'auteur: Transcription factors ; embryonic stem cells ; chromatin accessibility ; pioneer factors ; cell cycle ; OCT4 ; SOX2 ; differentiation.
SRY (sex determining region Y)-box 2 (SOX2) is one the embryonic stem cell transcription factors that is capable of reprogramming adult differentiated cells into an induced pluripotent cell. SOX2 is amplified in various types of epithelial cancers and its high its expression correlates with poor prognosis and decreased patient survival. Aberrant Wnt signaling drives the colo-rectal carcinogenic process and is a major determinant of the disease outcome. This study demonstrates that SOX2 counteracts Wnt driven tumor cell proliferation and maintains
CRISPR/Cas-9 system has been utilized in several model organisms to determine gene function via gene silencing and reverse genetics. While ample studies have been conducted in mice to uncover that pluripotency genes such as SRY-box 2 (SOX2) are highly expressed in embryonic stem cells (ESCs) and the inner cell mass (ICM), improved understanding of SOX2 function in cattle can potentially result in a valuable model for human preimplantation embryo development. Our study aimed to determine the efficiency of target mutations
Abstract : Aims: We recently reported that a small subset (7%) of oesophageal squamous cell carcinomas completely lacking SOX2 expression had unique clinicopathological features and a dismal prognosis. The aim of the present study was to elucidate whether the findings obtained in oesophageal cancers are applicable to hypopharyngeal squamous cell carcinomas (HPSCCs) or oropharyngeal squamous cell carcinomas (OPSCCs). Methods and results: The study cohort consisted of consecutive patients with HPSCC ( n =130) and OPSCC ( n =65) who underwent surgery without preoperative therapy. On immunostaining,