Spinal Interneurons in Sensorimotor Integration

Even though spinal cord research has expanded enormously during the past decades, we still lack a precise understanding of how spinal interneuron networks perfectly integrate sensory feedback with motor control, and how these neuron circuits give rise to specific functions. The present study thus has three basic aims: (1) to investigate propriospinal interneurons connecting rostral and caudal lumbar spinal cord in the rat; (2) to investigate input properties of identified spinal interneurons interposed in different pathways; (3) to investigate cholinergic terminals in the ventral horn of adult rat and cat. There was no evidence to support the presence of vesicular glutamate transporters in motoneuron axon terminals of either species. In addition, there was no obvious relationship between motoneuron terminals and R2 subunit of the AMPA receptor (GluR2). However, a population of cholinergic terminals in lamina VII, which did not originate from motoneurons, was found to be immunoreactive for VGLUT2 and formed appositions with GluR2 subunits. These terminals were smaller than motoneuron terminals and, unlike them, formed no relationship with Renshaw cells. The evidence suggests that glutamate does not act as a cotransmitter with acetylcholine at central synapses of motoneurons in the adult cat and rat. However, glutamate is present in a population of cholinergic terminals which probably originate from interneurons where its action is via an AMPA receptor. In conclusion, the present studies add to the understanding of the organization of neuronal networks involved in sensorimotor integration. Propriospinal interneurons located within the lumbar segments have extensive intra-segmental projections to motor nuclei. First order interneurons interposed in reflex pathways and descending pathways receive a significantly different pattern of inputs. A similar proportion of monosynaptic excitatory input from primary afferents has been found in both excitatory and inhibitory interneurons and these two types of cells are subject to presynaptic inhibitory control of this input.

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  • Author : Ting Ting Liu
  • Publisher : Anonim
  • Pages : 271 pages
  • ISBN :
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKSpinal Interneurons in Sensorimotor Integration

Spinal Interneurons in Sensorimotor Integration

Spinal Interneurons in Sensorimotor Integration
  • Author : Ting Ting Liu
  • Publisher : Unknown Publisher
  • Release : 21 January 2022
GET THIS BOOKSpinal Interneurons in Sensorimotor Integration

Even though spinal cord research has expanded enormously during the past decades, we still lack a precise understanding of how spinal interneuron networks perfectly integrate sensory feedback with motor control, and how these neuron circuits give rise to specific functions. The present study thus has three basic aims: (1) to investigate propriospinal interneurons connecting rostral and caudal lumbar spinal cord in the rat; (2) to investigate input properties of identified spinal interneurons interposed in different pathways; (3) to investigate cholinergic terminals in the

Spinal Interneurons

Spinal Interneurons
  • Author : Lyandysha Zholudeva,Michael Lane
  • Publisher : Academic Press
  • Release : 15 June 2021
GET THIS BOOKSpinal Interneurons

Spinal Interneurons: Plasticity after Spinal Cord Injury provides neuroscientists, clinicians and trainees a reference book exclusively concentrating on spinal interneurons and the techniques and experiments employed to identify and study these cells as part of normal, diseased and injured neural circuits. In addition, the book highlights the therapeutic potential of these cells by presenting relevant pre-clinical and clinical work that has been performed. The book's focus on the latest in therapeutic strategies for targeting spinal interneurons, considerations for the development

Lineage Tracing of Ipsilateral Ventral Spinal Interneurons Delineates a Sensorimotor Connectivity Map Based on Developmental Origin and Spatial Distribution

Lineage Tracing of Ipsilateral Ventral Spinal Interneurons Delineates a Sensorimotor Connectivity Map Based on Developmental Origin and Spatial Distribution
  • Author : Stefania Di Costanzo
  • Publisher : Unknown Publisher
  • Release : 21 January 2022
GET THIS BOOKLineage Tracing of Ipsilateral Ventral Spinal Interneurons Delineates a Sensorimotor Connectivity Map Based on Developmental Origin and Spatial Distribution

Movement is a fundamental behavior that is generated and patterned by premotor neural networks that reside in the ventral spinal cord of vertebrates. Despite ongoing investigations in multiple animal models, including humans, non-human primates, cats and rodents, identifying the functional neuron cell types that shape various motor tasks has proved difficult. One of the key issues in the field is the criteria by which neuronal cell types are characterized and defined. This dissertation describes my work tackling this problem using

Lumbar Spinal Interneuron Activity as it Relates to Rhythmic Motor Output in the Adult, Spinal, Air-stepping Cat

Lumbar Spinal Interneuron Activity as it Relates to Rhythmic Motor Output in the Adult, Spinal, Air-stepping Cat
  • Author : Chantal Marie McMahon
  • Publisher : Unknown Publisher
  • Release : 21 January 2022
GET THIS BOOKLumbar Spinal Interneuron Activity as it Relates to Rhythmic Motor Output in the Adult, Spinal, Air-stepping Cat

Interneurons of the lumbar spinal cord inherently maintain and modulate stepping. In order to advance therapeutic interventions for spinal cord injury, it is necessary to clearly understand both the localized locomotor spinal circuitry as well as the activation patterns within the spinal cord. In this study, the structural organization of interneurons regulating antagonistic motor pools and the neural activation patterns driving behavior were investigated. In-vivo extracellularly recorded neurons of the intermediate zone and ventral horn of the lumbar spinal cord

Deconstructing Spinal Interneurons, One Cell Type at a Time

Deconstructing Spinal Interneurons, One Cell Type at a Time
  • Author : Mariano Ignacio Gabitto
  • Publisher : Unknown Publisher
  • Release : 21 January 2022
GET THIS BOOKDeconstructing Spinal Interneurons, One Cell Type at a Time

By using our Sparse Bayesian approach, we showed that V1 interneurons, a major inhibitory population that controls motor output, fractionate into diverse subsets on the basis of the expression of nineteen transcription factors. Transcriptionally defined subsets exhibit highly structured spatial distributions with mediolateral and dorsoventral positional biases. These distinctions in settling position are largely predictive of patterns of input from sensory and motor neurons, arguing that settling position is a determinant of inhibitory microcircuit organization. Finally, we extensively validated inferred

The Neuroplastic and Therapeutic Potential of Interneurons in the Injured Spinal Cord

The Neuroplastic and Therapeutic Potential of Interneurons in the Injured Spinal Cord
  • Author : Lyandysha Viktorovna Zholudeva
  • Publisher : Unknown Publisher
  • Release : 21 January 2022
GET THIS BOOKThe Neuroplastic and Therapeutic Potential of Interneurons in the Injured Spinal Cord

There is a growing appreciation for spontaneous anatomical and functional changes, or neuroplasticity, after spinal cord injury. One key element of neuroplasticity recently identified are spinal interneurons. The work presented in this thesis identifies a specific population of spinal interneurons that contribute to respiratory plasticity -- the excitatory, ipsilaterally projecting population of V2a SpINs -- after high cervical spinal cord injury (Aim 1). Building upon these results, we transplanted neural progenitor cells enriched with stem-cell derived V2a interneurons and

Movement Control

Movement Control
  • Author : Paul Cordo,Stevan Harnad
  • Publisher : Cambridge University Press
  • Release : 27 May 1994
GET THIS BOOKMovement Control

This volume addresses issues about how the central nervous system controls movement.

Motor Neurobiology of the Spinal Cord

Motor Neurobiology of the Spinal Cord
  • Author : Timothy C. Cope
  • Publisher : CRC Press
  • Release : 26 June 2001
GET THIS BOOKMotor Neurobiology of the Spinal Cord

Traumatic injuries of the spinal cord continue to be the most common cause of permanent paralysis in young adults in the United States. New information has emerged on the response of spinal neurons to injury of either the spinal cord or peripheral nerves demonstrating that dendrites of injured motoneurons take on characteristics of axons. These and other new developments have helped to promote an exciting new era in the study of spinal cord neurobiology. Motor Neurobiology of the Spinal Cord

Peripheral and Spinal Mechanisms in the Neural Control of Movement

Peripheral and Spinal Mechanisms in the Neural Control of Movement
  • Author : M.D. Binder
  • Publisher : Elsevier
  • Release : 17 December 1999
GET THIS BOOKPeripheral and Spinal Mechanisms in the Neural Control of Movement

In the last decade, we have witnessed a striking maturation of our understanding of how neurons in the spinal cord control muscular activity and movement. Paradoxically, a host of new findings have revealed an unexpected versatility in the behavior of these well-studied neural elements and circuits. In this volume, the world's leading experts review the current state of our knowledge of motor control, outline their latest results and developments, and delineate the seminal unresolved questions in this vibrant field of