Spinal Muscular Atrophy

Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Produk Detail:

  • Author : Charlotte J Sumner
  • Publisher : Academic Press
  • Pages : 506 pages
  • ISBN : 0128036869
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKSpinal Muscular Atrophy

Spinal Muscular Atrophy

Spinal Muscular Atrophy
  • Author : Charlotte J Sumner,Sergey Paushkin,Chien-Ping Ko
  • Publisher : Academic Press
  • Release : 24 October 2016
GET THIS BOOKSpinal Muscular Atrophy

Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of

Spinal Muscular Atrophy

Spinal Muscular Atrophy
  • Author : Charlotte J. Sumner
  • Publisher : Academic Press
  • Release : 01 November 2016
GET THIS BOOKSpinal Muscular Atrophy

"Spinal Muscular Atrophy: Disease Mechanisms and Therapy" provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of

Spinal Muscular Atrophy: New Insights for the Healthcare Professional: 2011 Edition

Spinal Muscular Atrophy: New Insights for the Healthcare Professional: 2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 09 January 2012
GET THIS BOOKSpinal Muscular Atrophy: New Insights for the Healthcare Professional: 2011 Edition

Spinal Muscular Atrophy: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Spinal Muscular Atrophy in a compact format. The editors have built Spinal Muscular Atrophy: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Spinal Muscular Atrophy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and

Spinal Muscular Atrophy: New Insights for the Healthcare Professional: 2012 Edition

Spinal Muscular Atrophy: New Insights for the Healthcare Professional: 2012 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 10 December 2012
GET THIS BOOKSpinal Muscular Atrophy: New Insights for the Healthcare Professional: 2012 Edition

Spinal Muscular Atrophy: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Spinal Muscular Atrophy in a compact format. The editors have built Spinal Muscular Atrophy: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Spinal Muscular Atrophy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and

It's One of Them!

It's One of Them!
  • Author : Grace Saunders
  • Publisher : Author House
  • Release : 10 December 2014
GET THIS BOOKIt's One of Them!

Grace Saunders and her brother Ben were both born with the genetic disorder spinal muscular atrophy type 2/3, SMA. From her happy childhood growing up in Hertfordshire, enduring painful operations, to becoming a mom and a wife living an independent life in Coventry. Her extraordinary story of strength, not only coping with a severe physical disability, but being victim to domestic violence. Grace's story also involves drugs, murder, the police investigation that was Operation Ore and the death of her brother,

Neurodegenerative Diseases

Neurodegenerative Diseases
  • Author : Uday Kishore
  • Publisher : BoD – Books on Demand
  • Release : 15 May 2013
GET THIS BOOKNeurodegenerative Diseases

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It

Acutely ill infant

Acutely ill infant
  • Author : Sics Editore
  • Publisher : SICS Editore
  • Release : 01 October 2014
GET THIS BOOKAcutely ill infant

Signs and symptoms are often difficult to interpret in infants, so a complete examination must always be conducted. An infant may present with only a few signs even when seriously ill. The younger the infant, the more likely it is that the illness is serious and will require hospitalization. In practice, 3 months may be considered as the cut off point; particular vigilance should be exercised if the infant is less than 1 month old.Listen to the parents. A detailed history

Spinal Muscular Atrophy: A Patients Journey

Spinal Muscular Atrophy: A Patients Journey
  • Author : Shruti Kumar
  • Publisher : Unknown Publisher
  • Release : 19 January 2022
GET THIS BOOKSpinal Muscular Atrophy: A Patients Journey

Spinal Muscular Atrophy Background: Spinal Muscular Atrophy (SMA) is a rare, autosomal recessive, progressive, neurodegenerative disorder due to a genetic defect in SMN1 which, codes for the SMN protein- vital for motor neuron function. Subsequently, this leads to loss of anterior horn cell function in the spinal cord which manifests as multisystem skeletal muscle atrophy. Typically, proximal muscle weakness occurs first, however, once pulmonary musculature is affected, it leads to respiratory compromise and ultimately death. Case Description: We present two

Spinal Muscular Atrophy

Spinal Muscular Atrophy
  • Author : Deborah J. Nowak
  • Publisher : Unknown Publisher
  • Release : 19 January 1995
GET THIS BOOKSpinal Muscular Atrophy

"Spinal Muscular Atrophy (SMA) is one of many neuromuscular diseases affecting motor neurons and skeletal muscles. This disorder causes deterioration of the motor neurons (specifically the Anterior Horn Cells of the spinal cord). These motor neurons that control muscles are selectively destroyed resulting in varying degrees of atrophy, weakness and paralysis of the trunk and limb muscles. In this first half of the thesis report, various aspects of Spinal Muscular Atrophy, including history, anatomy/ physiology, diagnosis, theories of its function,

Characterization of Cellular Pathways in Spinal Muscular Atrophy

Characterization of Cellular Pathways in Spinal Muscular Atrophy
  • Author : Ferrill Franklin Rose
  • Publisher : Unknown Publisher
  • Release : 19 January 2022
GET THIS BOOKCharacterization of Cellular Pathways in Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is an autosomal recessive genetic disease, and is the leading genetic cause of death in infants. SMA is a severe neuromuscular disease characterized by loss of spinal [alpha]-motor neurons, resulting in the paralysis of skeletal muscle. SMA is caused by deficiency of Survival Motor Neuron (SMN) protein levels. Currently there is no effective treatment for SMA. The work presented in this thesis characterizes several potential SMA therapeutic targets. Follistatin is a natural antagonist of myostatin

Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases
  • Author : Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
  • Publisher : Academic Press
  • Release : 18 January 2017
GET THIS BOOKMolecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms.

The Role of Muscle and Nerve in Spinal Muscular Atrophy

The Role of Muscle and Nerve in Spinal Muscular Atrophy
  • Author : Chitra C. Iyer
  • Publisher : Unknown Publisher
  • Release : 19 January 2022
GET THIS BOOKThe Role of Muscle and Nerve in Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is the leading genetic cause of infant death, affecting approximately 1 in 10,000 live births worldwide. SMA is caused due to decrease in levels of the ubiquitous Survival Motor Neuron (SMN) protein. SMN in humans is encoded by two genes SMN1 and SMN2. SMA is an autosomal recessive disease caused due to deletion or mutation of SMN1 and retention of SMN2. Due to a C to T change in SMN2, the gene produces only small amounts of full-length