Stem Cell Bioprocessing

Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine. Maintains a unique focus on both the basic stem cell biology concepts, and their translation to large-scale bioprocessing approaches Envisages the use of stem cells in regenerative medicine and drug screening applications Discusses the application of microscale techniques as a tool to perform basic stem cell biology studies

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  • Author : Tiago G Fernandes
  • Publisher : Elsevier
  • Pages : 236 pages
  • ISBN : 1908818301
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKStem Cell Bioprocessing

Stem Cell Bioprocessing

Stem Cell Bioprocessing
  • Author : Tiago G Fernandes,Maria Margarida Diogo,Joaquim M. S. Cabral
  • Publisher : Elsevier
  • Release : 15 November 2013
GET THIS BOOKStem Cell Bioprocessing

Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different

Stem Cell Bioprocessing and Manufacturing

Stem Cell Bioprocessing and Manufacturing
  • Author : Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo
  • Publisher : MDPI
  • Release : 20 January 2021
GET THIS BOOKStem Cell Bioprocessing and Manufacturing

The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life

Bioprocessing for Cell-Based Therapies

Bioprocessing for Cell-Based Therapies
  • Author : Che J. Connon
  • Publisher : John Wiley & Sons
  • Release : 06 February 2017
GET THIS BOOKBioprocessing for Cell-Based Therapies

With contributions from leading, international academics and industrial practitioners, Bioprocessing for Cell-Based Therapies explores the very latest techniques and guidelines in bioprocess production to meet safety, regulatory and ethical requirements, for the production of therapeutic cells, including stem cells. An authoritative, cutting-edge handbook on bioprocessing for the production of therapeutic cells with extensive illustrations in full colour throughout An authoritative, cutting-edge handbook on bioprocessing for the production of therapeutic cells with extensive illustrations in full colour throughout In depth discussion

Bioreactors for Stem Cell Expansion and Differentiation

Bioreactors for Stem Cell Expansion and Differentiation
  • Author : Joaquim M.S. Cabral,Claudia Lobato da Silva
  • Publisher : CRC Press
  • Release : 03 September 2018
GET THIS BOOKBioreactors for Stem Cell Expansion and Differentiation

An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art

Stem Cell Manufacturing

Stem Cell Manufacturing
  • Author : Joaquim M. S. Cabral,Claudia Lobato da Silva,Lucas G. Chase,Maria Margarida Diogo
  • Publisher : Elsevier
  • Release : 24 July 2016
GET THIS BOOKStem Cell Manufacturing

Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
  • Author : Lucas G. Chase,Mohan C Vemuri
  • Publisher : Springer Science & Business Media
  • Release : 12 December 2012
GET THIS BOOKMesenchymal Stem Cell Therapy

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host

Stem Cell Engineering

Stem Cell Engineering
  • Author : Robert M. Nerem,Jeanne Loring,Todd C. McDevitt,Sean P. Palecek,David V. Schaffer,Peter W. Zandstra
  • Publisher : Springer
  • Release : 12 June 2014
GET THIS BOOKStem Cell Engineering

This book describes a global assessment of stem cell engineering research, achieved through site visits by a panel of experts to leading institutes, followed by dedicated workshops. The assessment made clear that engineers and the engineering approach with its quantitative, system-based thinking can contribute much to the progress of stem cell research and development. The increased need for complex computational models and new, innovative technologies, such as high-throughput screening techniques, organ-on-a-chip models and in vitro tumor models require an increasing

Stem Cells and Cell Therapy

Stem Cells and Cell Therapy
  • Author : Mohamed Al-Rubeai,Mariam Naciri
  • Publisher : Springer Science & Business Media
  • Release : 01 October 2013
GET THIS BOOKStem Cells and Cell Therapy

With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating

Bioreactors for Stem Cell Expansion and Differentiation

Bioreactors for Stem Cell Expansion and Differentiation
  • Author : Joaquim M.S. Cabral,Claudia Lobato da Silva
  • Publisher : CRC Press
  • Release : 03 September 2018
GET THIS BOOKBioreactors for Stem Cell Expansion and Differentiation

An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art

Bioprocess Engineering

Bioprocess Engineering
  • Author : Shijie Liu
  • Publisher : Newnes
  • Release : 28 September 2012
GET THIS BOOKBioprocess Engineering

Bioprocess Engineering involves the design and development of equipment and processes for the manufacturing of products such as food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials. It also deals with studying various biotechnological processes. "Bioprocess Kinetics and Systems Engineering" first of its kind contains systematic and comprehensive content on bioprocess kinetics, bioprocess systems, sustainability and reaction engineering. Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics-including batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction

Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts

Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts
  • Author : Claire Komives,Weichang Zhou
  • Publisher : John Wiley & Sons
  • Release : 27 December 2018
GET THIS BOOKBioprocessing Technology for Production of Biopharmaceuticals and Bioproducts

Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies

Cell Culture Bioprocess Engineering, Second Edition

Cell Culture Bioprocess Engineering, Second Edition
  • Author : Wei-Shou Hu
  • Publisher : CRC Press
  • Release : 11 March 2020
GET THIS BOOKCell Culture Bioprocess Engineering, Second Edition

This book is the culmination of three decades of accumulated experience in teaching biotechnology professionals. It distills the fundamental principles and essential knowledge of cell culture processes from across many different disciplines and presents them in a series of easy-to-follow, comprehensive chapters. Practicality, including technological advances and best practices, is emphasized. This second edition consists of major updates to all relevant topics contained within this work. The previous edition has been successfully used in training courses on cell culture bioprocessing