Stem Cells and Aging

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Produk Detail:

  • Author : Surajit Pathak
  • Publisher : Academic Press
  • Pages : 320 pages
  • ISBN : 0128204133
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKStem Cells and Aging

Stem Cells and Aging

Stem Cells and Aging
  • Author : Surajit Pathak,Antara Banerjee
  • Publisher : Academic Press
  • Release : 17 March 2021
GET THIS BOOKStem Cells and Aging

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen

Adult Stem Cells in Aging, Diseases and Cancer

Adult Stem Cells in Aging, Diseases and Cancer
  • Author : K.L. Rudolph
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 22 December 2014
GET THIS BOOKAdult Stem Cells in Aging, Diseases and Cancer

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment.

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
  • Author : Lucas G. Chase,Mohan C Vemuri
  • Publisher : Springer Science & Business Media
  • Release : 12 December 2012
GET THIS BOOKMesenchymal Stem Cell Therapy

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation
  • Author : Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
  • Publisher : Springer
  • Release : 06 July 2015
GET THIS BOOKStem Cell Aging: Mechanisms, Consequences, Rejuvenation

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality

Stem Cells and Aging

Stem Cells and Aging
  • Author : Cesar V. Borlongan,Gary K. Steinberg
  • Publisher : Frontiers Media SA
  • Release : 14 July 2021
GET THIS BOOKStem Cells and Aging

Dr. Borlongan and Dr. Steinberg serve as consultants to stem cell-based companies, hold patents and patent applications, and have funded grants related to stem cell biologics and applications.

Stem Cells and Aging

Stem Cells and Aging
  • Author : Kursad Turksen
  • Publisher : Humana Press
  • Release : 13 February 2013
GET THIS BOOKStem Cells and Aging

Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
  • Author : Rakesh Sharma
  • Publisher : BoD – Books on Demand
  • Release : 02 May 2018
GET THIS BOOKStem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
  • Author : Susie Prof. Nilsson
  • Publisher : Academic Press
  • Release : 22 August 2020
GET THIS BOOKThe Stem Cell Niche during Ageing

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on

How and why We Age

How and why We Age
  • Author : Leonard Hayflick
  • Publisher : Unknown Publisher
  • Release : 01 January 1996
GET THIS BOOKHow and why We Age

A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

Exosomes, Stem Cells and MicroRNA

Exosomes, Stem Cells and MicroRNA
  • Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
  • Publisher : Springer
  • Release : 12 May 2018
GET THIS BOOKExosomes, Stem Cells and MicroRNA

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well

Telomeres and Telomerase in Aging, Disease, and Cancer

Telomeres and Telomerase in Aging, Disease, and Cancer
  • Author : K. Lenhard Rudolph
  • Publisher : Springer Science & Business Media
  • Release : 07 November 2007
GET THIS BOOKTelomeres and Telomerase in Aging, Disease, and Cancer

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease
  • Author : Pura Muñoz-Cánoves,Jaime J. Carvajal,Adolfo Lopez de Munain,Ander Izeta
  • Publisher : Frontiers Media SA
  • Release : 29 June 2016
GET THIS BOOKRole of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it

Models, Molecules and Mechanisms in Biogerontology

Models, Molecules and Mechanisms in Biogerontology
  • Author : Pramod C. Rath
  • Publisher : Springer Nature
  • Release : 26 June 2020
GET THIS BOOKModels, Molecules and Mechanisms in Biogerontology

The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
  • Author : Suresh I.S. Rattan,Leonard Hayflick
  • Publisher : Springer
  • Release : 09 May 2016
GET THIS BOOKCellular Ageing and Replicative Senescence

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to