Stem Cells and Aging

Little is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as well as attempting to define the role of dysfunctional stem cells in the aging process. Stem Cells and Aging will guide the reader to a better understanding of how stem cells age might have a key role in deciphering the normal aging process. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Produk Detail:

  • Author : Surajit Pathak
  • Publisher : Academic Press
  • Pages : 200 pages
  • ISBN : 9780128200711
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKStem Cells and Aging

Stem Cells and Aging

Stem Cells and Aging
  • Author : Surajit Pathak
  • Publisher : Academic Press
  • Release : 15 March 2021
GET THIS BOOKStem Cells and Aging

Little is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
  • Author : Rakesh Sharma
  • Publisher : BoD – Books on Demand
  • Release : 02 May 2018
GET THIS BOOKStem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters

Adult Stem Cells in Aging, Diseases and Cancer

Adult Stem Cells in Aging, Diseases and Cancer
  • Author : K.L. Rudolph
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 22 December 2014
GET THIS BOOKAdult Stem Cells in Aging, Diseases and Cancer

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment.

Antiaging - Effect of Stem Cells on Aging and Stem Cell Aging

Antiaging - Effect of Stem Cells on Aging and Stem Cell Aging
  • Author : Jisook Moon
  • Publisher : Unknown Publisher
  • Release : 26 January 2021
GET THIS BOOKAntiaging - Effect of Stem Cells on Aging and Stem Cell Aging

Aging is defined broadly as the normal progressive process, consequently leading to growing vulnerability to disease and death. A major challenge lies in dissecting the underlying mechanisms of aging with conventional experiments due to the complexity of and multicontributions to the aging process, reflecting a need for investigation into it in various aspects. For this reason, the age process has currently been subjected to OMICS technologies including genomics, transcriptomics, proteomics, and metabolomics, allowing the exploration of age-related changes in a

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation
  • Author : Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
  • Publisher : Springer
  • Release : 06 July 2015
GET THIS BOOKStem Cell Aging: Mechanisms, Consequences, Rejuvenation

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality

Telomeres and Telomerase in Aging, Disease, and Cancer

Telomeres and Telomerase in Aging, Disease, and Cancer
  • Author : K. Lenhard Rudolph
  • Publisher : Springer Science & Business Media
  • Release : 07 November 2007
GET THIS BOOKTelomeres and Telomerase in Aging, Disease, and Cancer

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Progress in Stem Cell Transplantation

Progress in Stem Cell Transplantation
  • Author : Taner Demirer
  • Publisher : BoD – Books on Demand
  • Release : 02 December 2015
GET THIS BOOKProgress in Stem Cell Transplantation

This book documents the increased amount of stem cell-related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies discussed in basic and clinical chapters from authors around the world involved in stem cell studies and research. It thereby complements and extends the basic coverage of stem cells, such as mesenchymal stem cells, effect of stem cells on aging, cover hematopoietic

Stem Cells and Aging

Stem Cells and Aging
  • Author : Kursad Turksen
  • Publisher : Humana Press
  • Release : 13 February 2013
GET THIS BOOKStem Cells and Aging

Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and

Frailty and Sarcopenia

Frailty and Sarcopenia
  • Author : Yannis Dionyssiotis
  • Publisher : BoD – Books on Demand
  • Release : 30 August 2017
GET THIS BOOKFrailty and Sarcopenia

Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
  • Author : Lucas G. Chase,Mohan C Vemuri
  • Publisher : Springer Science & Business Media
  • Release : 12 December 2012
GET THIS BOOKMesenchymal Stem Cell Therapy

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host

Exosomes, Stem Cells and MicroRNA

Exosomes, Stem Cells and MicroRNA
  • Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
  • Publisher : Springer
  • Release : 07 April 2018
GET THIS BOOKExosomes, Stem Cells and MicroRNA

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
  • Author : Susie Prof. Nilsson
  • Publisher : Academic Press
  • Release : 22 August 2020
GET THIS BOOKThe Stem Cell Niche during Ageing

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on

How and why We Age

How and why We Age
  • Author : Leonard Hayflick
  • Publisher : Unknown Publisher
  • Release : 01 January 1996
GET THIS BOOKHow and why We Age

A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease
  • Author : Pura Muñoz-Cánoves,Jaime J. Carvajal,Adolfo Lopez de Munain,Ander Izeta
  • Publisher : Frontiers Media SA
  • Release : 29 June 2016
GET THIS BOOKRole of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease

Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it

Advances in Stem Cell Aging

Advances in Stem Cell Aging
  • Author : K. Lenhard Rudolph
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 26 January 2021
GET THIS BOOKAdvances in Stem Cell Aging

Up-to-date meeting report of the Else Kr ner-Fresenius Symposium on Adult Stem Cell Aging Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration,