Strategies and Tactics in Organic Synthesis

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, this book vividly demonstrates through first hand accounts how synthesis is really done and how by discovering new reactions, creating new designs and building molecules with atom and step economies, the advancement of the science of organic synthesis is providing solutions through function to create a better world. Presents state-of-the-art developments in organic synthesis Provides insight and offers new perspective to problem-solving Written by leading experts in the field

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  • Author : Michael Harmata
  • Publisher : Academic Press
  • Pages : 460 pages
  • ISBN : 0123865395
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKStrategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Academic Press
  • Release : 31 December 2012
GET THIS BOOKStrategies and Tactics in Organic Synthesis

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, this book vividly demonstrates through first hand accounts how synthesis is really done and how by discovering new reactions, creating new designs and building molecules with atom and step economies, the advancement of the science of organic synthesis

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Thomas Lindberg
  • Publisher : Academic Press
  • Release : 02 December 2012
GET THIS BOOKStrategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology. Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to

Strategies and Tactics in Organic Synthesis. Vol. 5

Strategies and Tactics in Organic Synthesis. Vol. 5
  • Author : Michael Harmata
  • Publisher : Unknown Publisher
  • Release : 21 January 2022
GET THIS BOOKStrategies and Tactics in Organic Synthesis. Vol. 5

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the

Strategies and Tactics In Organic Synthesis

Strategies and Tactics In Organic Synthesis
  • Author : Thomas Lindberg
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKStrategies and Tactics In Organic Synthesis

Strategies and Tactics in Organic Synthesis presents the chronological development of ideas and experimentation in organic synthesis. This book is organized into 13 chapters that explore the synthetic pathways of various organic compounds. The first four chapters describe the variations in the synthesis of superphane, gibberellic acid, prostaglandin, and alkaloids. The following chapters cover the organic synthesis and biosynthesis of tylonolide, endiandric acids A-G, dodecahedrane, fomannosin, and illudol. A chapter focuses on the evolution of the total synthesis of jatrophone, an

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOKStrategies and Tactics in Organic Synthesis

This chapter defines risk-taking in organic synthesis as the deliberate pursuit of strategies that do not have near neighbors in the chemical literature. In these ventures into the unknown, chemical behavior can be difficult to predict. The literature of organic chemistry is replete with examples of powerful, bond-forming strategies that had little or no precedent when they were developed. This essay addresses some of those examples in an effort to demonstrate the merits of creative risk-taking in the planning and

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Elsevier
  • Release : 19 April 2004
GET THIS BOOKStrategies and Tactics in Organic Synthesis

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Masayuki Inoue,Daisuke Urabe
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOKStrategies and Tactics in Organic Synthesis

In this chapter, we described the asymmetric total synthesis of merrilactone A and resolvin E2 based on the symmetry-driven strategy. The enantio- and diastereoselective transannular aldol reaction of the meso eight-membered diketone led to the efficient total syntheses of both enantiomers of merrilactone A, and the convergent assembly of the pseudo-enantiomeric fragments, prepared through the enantioselective solvolysis of the meso intermediate, resulted in total synthesis of resolvin E2. These syntheses demonstrate the power and generality of the symmetry-driven strategy for

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Academic Press
  • Release : 19 November 2019
GET THIS BOOKStrategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis, Volume 14, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Jason M. Tenenbaum,William J. Morris,Daniel W. Custar,Karl A. Scheidt
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOKStrategies and Tactics in Organic Synthesis

This account describes the convergent synthesis of (−)-okilactomycin. The first-generation approach focused on the assembly of two complex fragments through a Prins reaction of a dioxinone and α-hydroxy aldehyde. While this route was not ultimately successful, a related Maitland–Japp process employing a β-keto ester in place of the dioxinone fragment provided the necessary union of functionalized intermediate, thereby establishing the full carbon framework of the natural product. The synthesis also employed a highly diastereoselective Lewis acid-promoted Diels–Alder reaction

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael F. Greaney,Lei Shi,Naim Nazef
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOKStrategies and Tactics in Organic Synthesis

This chapter describes the synthesis of two related sesquiterpenes, anislactone A and merrilactone A. We initially accessed a tetracyclic oxetane in the merrilactone series using a Paternò–Büchi reaction but found the compound to be too underfunctionalized to advance further. We then developed an approach based on reductive epoxide ring opening, whereby a fully elaborated C-ring epoxy-cyclopentane, containing five stereocenters, could undergo reductive epoxide cleavage when treated with Ti(III). The resulting tertiary radical then participates in a 5-exo-dig

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : William J. Chain
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOKStrategies and Tactics in Organic Synthesis

Englerin A is a guaiane sesquiterpene with potent and selective growth inhibition activity against six human renal cancer cell lines. Englerin A has captured the attention of the synthetic organic chemistry community owing to its exciting activity and its attractive polycyclic and functionalized structure. This document describes the process by which we developed a carbonyl-based synthesis of the natural product that relies upon simple, inexpensive starting materials. Utilizing a diastereoselective Michael addition reaction, followed by a remarkably selective samarium-mediated carbonyl-alkene

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Gopal Sirasani,Rodrigo B. Andrade
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOKStrategies and Tactics in Organic Synthesis

Described herein is an account of my laboratory’s entry into the magnificent field of complex alkaloid total synthesis, spanning the development of novel methods for quickly assembling polycyclic frameworks through the total synthesis of various members of the Strychnos alkaloids. A discussion of the prior art related to our approach to these alkaloids in addition to strategic decisions and reasoning made en route to targets akuammicine ( 1 ), strychnine ( 2 ), and leuconicines A ( 3 ) and B ( 4 ) is carefully detailed. Finally, we present the

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Joseph D. Panarese,Stephen P. Waters
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 July 2013
GET THIS BOOKStrategies and Tactics in Organic Synthesis

In 2008, (+)-aspergillide C, a structurally novel marine metabolite bearing a 14-membered macrolactone around a 2,6-dihydropyran core, was isolated from a marine-derived fungus, Aspergillus ostianus. In a biological assay, (+)-aspergillide C displayed promising anticancer activity (LD50=2.0μg/ml) against mouse lymphocytic leukemia cells (L1210). Due to its notable biological activity and interesting architecture, we viewed aspergillide C as an attractive synthetic target. Moreover, the aspergillide scaffold could lend itself to diverse structural modifications in projected syntheses of biologically active congeners. In