Structural Biology Using Electrons and X rays

Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen’s symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles). This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics. Emphasis on common principles underlying all diffraction-based methods Thorough grounding in theory requires understanding of only simple algebra Visual representations and explanations of challenging content Mathematical detail offered in short-course form to parallel the text

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  • Author : Michael F Moody
  • Publisher : Academic Press
  • Pages : 450 pages
  • ISBN : 9780080919454
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKStructural Biology Using Electrons and X rays

Structural Biology Using Electrons and X-rays

Structural Biology Using Electrons and X-rays
  • Author : Michael F Moody
  • Publisher : Academic Press
  • Release : 03 March 2011
GET THIS BOOKStructural Biology Using Electrons and X-rays

Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier

The Resolution Revolution: Recent Advances In cryoEM

The Resolution Revolution: Recent Advances In cryoEM
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 26 August 2016
GET THIS BOOKThe Resolution Revolution: Recent Advances In cryoEM

cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging. Continues the legacy of this premier serial

Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications

Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications
  • Author : Anonim
  • Publisher : World Scientific
  • Release : 22 January 2022
GET THIS BOOKAstroparticle, Particle and Space Physics, Detectors and Medical Physics Applications

The exploration of the subnuclear world is done through increasingly complex experiments covering a wide range of energies and in a large variety of environments OCo from particle accelerators and underground detectors to satellites and space laboratories. For these research programs to succeed, novel techniques, new materials and new instrumentation need to be used in detectors, often on a large scale. Hence, particle physics is at the forefront of technological advancement and leads to numerous applications. Among these, medical applications

X-Ray Free Electron Lasers

X-Ray Free Electron Lasers
  • Author : Uwe Bergmann,Vittal Yachandra,Junko Yano
  • Publisher : Royal Society of Chemistry
  • Release : 11 August 2017
GET THIS BOOKX-Ray Free Electron Lasers

The ultra-bright femtosecond X-ray pulses provided by X-ray free electron lasers (XFELs) open up opportunities to study the structure and dynamics of a wide variety of systems beyond what is possible with synchrotron sources. This book introduces the principles and properties of currently operating and future XFELs, before outlining applications in materials science, chemistry and biology. Edited by pioneers in this exciting field, and featuring contributions from leading researchers, this book is ideal for researchers working with XFELs, synchrotron radiation,

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery
  • Author : Jean-Paul Renaud
  • Publisher : John Wiley & Sons
  • Release : 05 February 2020
GET THIS BOOKStructural Biology in Drug Discovery

With the most comprehensive and up-to-date overview of structure-based drug discovery and using experimental and computational approaches, this book covers principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Presents the benefits, limitations, and potentiality of novel techniques in the field, like complex crystallization, X-ray diffraction, NMR, mass spectrometry, and computational chemistry Assesses macromolecular structures with experimental, analytical, and therapeutic approaches to reveal a successful, multidisciplinary perspective to drug development Includes detailed

Advances in Protein Molecular and Structural Biology Methods

Advances in Protein Molecular and Structural Biology Methods
  • Author : Timir Tripathi,Vikash Kumar Dubey
  • Publisher : Academic Press
  • Release : 14 January 2022
GET THIS BOOKAdvances in Protein Molecular and Structural Biology Methods

Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied

Electron Probe Microanalysis

Electron Probe Microanalysis
  • Author : Karl Zierold,Herbert K. Hagler
  • Publisher : Springer Science & Business Media
  • Release : 08 March 2013
GET THIS BOOKElectron Probe Microanalysis

The aim of electron probe microanalysis of biological systems is to identify, localize, and quantify elements, mass, and water in cells and tissues. The method is based on the idea that all electrons and photons emerging from an electron beam irradiated specimen contain information on its structure and composition. In particular, energy spectroscopy of X-rays and electrons after interaction of the electron beam with the specimen is used for this purpose. However, the application of this method in biology and

X-Ray Microscopy and Spectromicroscopy

X-Ray Microscopy and Spectromicroscopy
  • Author : Jürgen Thieme,Günter Schmahl,Dietbert Rudolph,Eberhard Umbach
  • Publisher : Springer Science & Business Media
  • Release : 09 November 2013
GET THIS BOOKX-Ray Microscopy and Spectromicroscopy

This book is based on presentations to the International Conference of X-Ray Micro scopy and Spectromicroscopy, XRM 96, which took place in Wiirzburg, August 19- 23, 1996. The conference also celebrated the lOOth anniversary of the discovery of X rays by Wilhelm Conrad Rontgen on November 8, 1895, in Wiirzburg. This book contains state-of-the-art reviews and up-to-date progress reports in the field of X-ray microscopy and spectromicroscopy, including related new X-ray optics and X-ray sources. It reflects the lively activities within a relatively new field

X-ray Free Electron Lasers

X-ray Free Electron Lasers
  • Author : Sébastien Boutet,Petra Fromme,Mark S. Hunter
  • Publisher : Springer
  • Release : 27 December 2018
GET THIS BOOKX-ray Free Electron Lasers

The timely volume describes recent discoveries and method developments that have revolutionized Structural Biology with the advent of X-ray Free Electron Lasers. It provides, for the first time, a comprehensive examination of this cutting-edge technology. It discusses of-the-moment topics such as growth and detection of nanocrystals, Sample Delivery Techniques for serial femtosecond crystallography, data collection methods at XFELs, and more. This book aims to provide the readers with an overview of the new methods that have been recently developed as

X-Ray Charge Densities and Chemical Bonding

X-Ray Charge Densities and Chemical Bonding
  • Author : Philip Coppens
  • Publisher : Oxford University Press on Demand
  • Release : 08 May 1997
GET THIS BOOKX-Ray Charge Densities and Chemical Bonding

This book deals with the electron density distribution in molecules and solids as obtained experimentally by X-ray diffraction. It is a comprehensive treatment of the methods involved, and the interpretation of the experimental results in terms of chemical bonding and intermolecular interactions. Inorganic and organic solids, as well as metals, are covered in the chapters dealing with specific systems. As a whole, this monograph is especially appealing because of its broad interface with numerous disciplines. Accurate X-ray diffraction intensities contain

Integrative Structural Biology with Hybrid Methods

Integrative Structural Biology with Hybrid Methods
  • Author : Haruki Nakamura,Gerard Kleywegt,Stephen K. Burley,John L. Markley
  • Publisher : Springer
  • Release : 08 January 2019
GET THIS BOOKIntegrative Structural Biology with Hybrid Methods

This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and

Lecture Notes on Computational Structural Biology

Lecture Notes on Computational Structural Biology
  • Author : Zhijun Wu
  • Publisher : World Scientific
  • Release : 22 January 2022
GET THIS BOOKLecture Notes on Computational Structural Biology

While the field of computational structural biology or structural bioinformatics is rapidly developing, there are few books with a relatively complete coverage of such diverse research subjects studied in the field as X-ray crystallography computing, NMR structure determination, potential energy minimization, dynamics simulation, and knowledge-based modeling. This book helps fill the gap by providing such a survey on all the related subjects. Comprising a collection of lecture notes for a computational structural biology course for the Program on Bioinformatics and

Mass Spectrometry in Structural Biology and Biophysics

Mass Spectrometry in Structural Biology and Biophysics
  • Author : Igor A. Kaltashov,Stephen J. Eyles
  • Publisher : John Wiley & Sons
  • Release : 03 April 2012
GET THIS BOOKMass Spectrometry in Structural Biology and Biophysics

With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues. The book presents a discussion of general biophysical concepts and a brief overview of traditional biophysical techniques before outlining the more advanced concepts of mass spectrometry. The new edition gives an up-to-date and expanded coverage of experimental methodologies and a

X-Ray Microscopy

X-Ray Microscopy
  • Author : Chris Jacobsen
  • Publisher : Cambridge University Press
  • Release : 19 December 2019
GET THIS BOOKX-Ray Microscopy

A complete introduction to x-ray microscopy, covering optics, 3D and chemical imaging, lensless imaging, radiation damage, and applications.