Composition and Function of the Extracellular Matrix in the Human Body

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

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  • Author : Francesco Travascio
  • Publisher : BoD – Books on Demand
  • Pages : 374 pages
  • ISBN : 9535124153
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKComposition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body
  • Author : Francesco Travascio
  • Publisher : BoD – Books on Demand
  • Release : 15 June 2016
GET THIS BOOKComposition and Function of the Extracellular Matrix in the Human Body

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
  • Author : Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release : 16 February 2011
GET THIS BOOKThe Extracellular Matrix: an Overview

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept

Calcific Aortic Valve Disease

Calcific Aortic Valve Disease
  • Author : Elena Aikawa
  • Publisher : BoD – Books on Demand
  • Release : 12 June 2013
GET THIS BOOKCalcific Aortic Valve Disease

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment

Cell Biology of Extracellular Matrix

Cell Biology of Extracellular Matrix
  • Author : E.D. Hay
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2013
GET THIS BOOKCell Biology of Extracellular Matrix

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For

Evolution of Extracellular Matrix

Evolution of Extracellular Matrix
  • Author : Fred W. Keeley,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release : 15 March 2013
GET THIS BOOKEvolution of Extracellular Matrix

The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of

Tissue Regeneration

Tissue Regeneration
  • Author : Hussein Abdelhay Essayed Kaoud
  • Publisher : BoD – Books on Demand
  • Release : 06 June 2018
GET THIS BOOKTissue Regeneration

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different

Extracellular Matrix Degradation

Extracellular Matrix Degradation
  • Author : William C. Parks,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release : 07 April 2011
GET THIS BOOKExtracellular Matrix Degradation

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases,

Extracellular Matrix Biology

Extracellular Matrix Biology
  • Author : Richard O. Hynes,Kenneth M. Yamada
  • Publisher : Unknown Publisher
  • Release : 24 January 2022
GET THIS BOOKExtracellular Matrix Biology

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in the regulation of cell function. ECM proteins bind to cell surface receptors such as integrins, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. This book covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during tumorigenesis and other disease states.

Mimicking the Extracellular Matrix

Mimicking the Extracellular Matrix
  • Author : Gregory A Hudalla,William L Murphy
  • Publisher : Royal Society of Chemistry
  • Release : 15 March 2019
GET THIS BOOKMimicking the Extracellular Matrix

The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
  • Author : Robert Mecham
  • Publisher : Springer
  • Release : 25 March 2011
GET THIS BOOKThe Extracellular Matrix: an Overview

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept

Cellular Organelles and the Extracellular Matrix

Cellular Organelles and the Extracellular Matrix
  • Author : Edward Bittar
  • Publisher : Elsevier
  • Release : 04 January 1996
GET THIS BOOKCellular Organelles and the Extracellular Matrix

This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these

Extracellular Matrix in Development

Extracellular Matrix in Development
  • Author : Douglas W. DeSimone,Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release : 15 March 2013
GET THIS BOOKExtracellular Matrix in Development

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental

Extracellular Matrix: Pathobiology and Signaling

Extracellular Matrix: Pathobiology and Signaling
  • Author : Nikos Karamanos
  • Publisher : Walter de Gruyter
  • Release : 31 August 2012
GET THIS BOOKExtracellular Matrix: Pathobiology and Signaling

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting.

Second Harmonic Generation Imaging

Second Harmonic Generation Imaging
  • Author : Francesco S. Pavone,Paul J. Campagnola
  • Publisher : Taylor & Francis
  • Release : 19 April 2016
GET THIS BOOKSecond Harmonic Generation Imaging

Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical applications. The book features contributions by experts in second-harmonic imaging, including many pioneering researchers in the field. Written for researchers at all levels, it takes an in-depth look at the current state of the