Systems Biomedicine

Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable Includes a thorough discussion of the applications of quantitative principles to biomedical problems

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  • Author : Edison T. Liu
  • Publisher : Academic Press
  • Pages : 448 pages
  • ISBN : 9780080919836
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKSystems Biomedicine

Systems Biomedicine

Systems Biomedicine
  • Author : Edison T. Liu,Douglas A. Lauffenburger
  • Publisher : Academic Press
  • Release : 17 September 2009
GET THIS BOOKSystems Biomedicine

Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying

Comprehensive Systems Biomedicine

Comprehensive Systems Biomedicine
  • Author : Pietro Lio,Enrico Capobianco
  • Publisher : Frontiers E-books
  • Release : 03 December 2014
GET THIS BOOKComprehensive Systems Biomedicine

Systems Biomedicine is a field in perpetual development. By definition a translational discipline, it emphasizes the role of quantitative systems approaches in biomedicine and aims to offer solutions to many emerging problems characterized by levels and types of complexity and uncertainty unmet before. Many factors, including technological and societal ones, need to be considered. In particular, new technologies are providing researchers with the data deluge whose management and exploitation requires a reinvention of cross-disciplinary team efforts. The advent of “omics”

New Challenges for Cancer Systems Biomedicine

New Challenges for Cancer Systems Biomedicine
  • Author : Alberto D'Onofrio,Paola Cerrai,Alberto Gandolfi
  • Publisher : Springer Science & Business Media
  • Release : 25 January 2013
GET THIS BOOKNew Challenges for Cancer Systems Biomedicine

The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the

Complex Systems in Biomedicine

Complex Systems in Biomedicine
  • Author : A. Quarteroni,L. Formaggia,A. Veneziani
  • Publisher : Springer Science & Business Media
  • Release : 20 March 2007
GET THIS BOOKComplex Systems in Biomedicine

Mathematicalmodelingofhumanphysiopathologyisatremendouslyambitioustask. It encompasses the modeling of most diverse compartments such as the cardiovas- lar,respiratory,skeletalandnervoussystems,aswellasthemechanicalandbioch- ical interaction between blood ?ow and arterial walls, and electrocardiac processes and electric conduction in biological tissues. Mathematical models can be set up to simulate both vasculogenesis (the aggregation and organization of endothelial cells dispersed in a given environment) and angiogenesis (the formation of new vessels sprouting from an existing vessel) that are relevant to the formation of vascular networks, and in particular

Biomedicine and Alternative Healing Systems in America

Biomedicine and Alternative Healing Systems in America
  • Author : Hans A. Baer
  • Publisher : Univ of Wisconsin Press
  • Release : 22 September 2021
GET THIS BOOKBiomedicine and Alternative Healing Systems in America

Examining medical pluralism in the United States from the Revolutionary War period through the end of the twentieth century, Hans Baer brings together in one convenient reference a vast array of information on healing systems as diverse as Christian Science, osteopathy, acupuncture, evangelical faith healing, Santeria, southern Appalachian herbalism, and Navajo healing. In a country where the dominant paradigm of biomedicine (medical schools, research hospitals, clinics staffed by M.D.s and R.N.s) has been long established and

Complex Systems Science in Biomedicine

Complex Systems Science in Biomedicine
  • Author : Thomas Deisboeck,J. Yasha Kresh
  • Publisher : Springer Science & Business Media
  • Release : 13 June 2007
GET THIS BOOKComplex Systems Science in Biomedicine

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing

Systems Biology in Cancer Research and Drug Discovery

Systems Biology in Cancer Research and Drug Discovery
  • Author : Asfar S Azmi
  • Publisher : Springer Science & Business Media
  • Release : 29 September 2012
GET THIS BOOKSystems Biology in Cancer Research and Drug Discovery

Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and

Edinburgh Companion to the Critical Medical Humanities

Edinburgh Companion to the Critical Medical Humanities
  • Author : Anne Whitehead
  • Publisher : Edinburgh University Press
  • Release : 30 June 2016
GET THIS BOOKEdinburgh Companion to the Critical Medical Humanities

In this landmark Companion, expert contributors from around the world map out the field of the critical medical humanities. This is the first volume to introduce comprehensively the ways in which interdisciplinary thinking across the humanities and social sciences might contribute to, critique and develop medical understanding of the human individually and collectively. The thirty-six newly commissioned chapters range widely within and across disciplinary fields, always alert to the intersections between medicine, as broadly defined, and critical thinking. Each chapter

Systems Biology

Systems Biology
  • Author : Aleš Prokop,Béla Csukás
  • Publisher : Springer Science & Business Media
  • Release : 28 August 2013
GET THIS BOOKSystems Biology

Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing

Single Cell Biomedicine

Single Cell Biomedicine
  • Author : Jianqin Gu,Xiangdong Wang
  • Publisher : Springer
  • Release : 25 June 2018
GET THIS BOOKSingle Cell Biomedicine

The book focuses on various detection targets applied in single cell studies, including tumor tissue cells, circulating tumor cells (CTCs), disseminated tumor cells (DTCs), circulating tumor DNA (ctDNA), cell-free DNA (cfDNA) and cancer stem cells (CSCs). It also discusses and compares detection methods using these detection targets in different fields to reveal single cell biomedical functions. The volume focuses not only on the methods already been established and validated, and also the methods newly developed. The book also highlights the

Systems Medicine

Systems Medicine
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 August 2020
GET THIS BOOKSystems Medicine

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and

Philosophy of Systems Biology

Philosophy of Systems Biology
  • Author : Sara Green
  • Publisher : Springer
  • Release : 15 December 2016
GET THIS BOOKPhilosophy of Systems Biology

The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the

Metadata-driven Software Systems in Biomedicine

Metadata-driven Software Systems in Biomedicine
  • Author : Prakash M. Nadkarni
  • Publisher : Springer Science & Business Media
  • Release : 27 May 2011
GET THIS BOOKMetadata-driven Software Systems in Biomedicine

While the use of database technology is ubiquitous throughout IT (and health IT in particular), it is not generally appreciated that, as a database increases in scope, certain designs are far superior to others. In biomedical domains, new knowledge is being generated continually, and the databases that must support areas such as clinical care and research must also be able to evolve while requiring minimal or no logical / physical redesign. Appropriately designed metadata, and software designed to utilize it effectively,