Target Validation in Drug Discovery

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

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  • Author : Brian W. Metcalf
  • Publisher : Elsevier
  • Pages : 296 pages
  • ISBN : 9780080465975
  • Rating : 3/5 from 1 reviews
CLICK HERE TO GET THIS BOOKTarget Validation in Drug Discovery

Target Validation in Drug Discovery

Target Validation in Drug Discovery
  • Author : Brian W. Metcalf,Susan Dillon
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKTarget Validation in Drug Discovery

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and

Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
  • Author : Jürgen Moll,Sebastian Carotta
  • Publisher : Humana Press
  • Release : 12 April 2019
GET THIS BOOKTarget Identification and Validation in Drug Discovery

This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips

Target Discovery and Validation

Target Discovery and Validation
  • Author : Alleyn T. Plowright
  • Publisher : John Wiley & Sons
  • Release : 31 December 2019
GET THIS BOOKTarget Discovery and Validation

The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling,

Phenotypic Drug Discovery

Phenotypic Drug Discovery
  • Author : Beverley Isherwood,Angelique Augustin
  • Publisher : Royal Society of Chemistry
  • Release : 10 December 2020
GET THIS BOOKPhenotypic Drug Discovery

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and

Platform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 21 November 2017
GET THIS BOOKPlatform Technologies in Drug Discovery and Validation

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique

The Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry

The Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry
  • Author : Stephanie K. Ashenden
  • Publisher : Academic Press
  • Release : 23 April 2021
GET THIS BOOKThe Era of Artificial Intelligence, Machine Learning, and Data Science in the Pharmaceutical Industry

The Era of Artificial Intelligence, Machine Learning and Data Science in the Pharmaceutical Industry examines the drug discovery process, assessing how new technologies have improved effectiveness. Artificial intelligence and machine learning are considered the future for a wide range of disciplines and industries, including the pharmaceutical industry. In an environment where producing a single approved drug costs millions and takes many years of rigorous testing prior to its approval, reducing costs and time is of high interest. This book follows

Protein Degradation with New Chemical Modalities

Protein Degradation with New Chemical Modalities
  • Author : Hilmar Weinmann,Craig Crews
  • Publisher : Royal Society of Chemistry
  • Release : 07 October 2020
GET THIS BOOKProtein Degradation with New Chemical Modalities

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in

Cheminformatics and its Applications

Cheminformatics and its Applications
  • Author : Amalia Stefaniu,Azhar Rasul,Ghulam Hussain
  • Publisher : BoD – Books on Demand
  • Release : 15 July 2020
GET THIS BOOKCheminformatics and its Applications

Cheminformatics has emerged as an applied branch of Chemistry that involves multidisciplinary knowledge, connecting related fields such as chemistry, computer science, biology, pharmacology, physics, and mathematical statistics.The book is organized in two sections, including multiple aspects related to advances in the development of informatic tools and their specific use in compound structure databases with various applications in life sciences, mainly in medicinal chemistry, for identification and development of new therapeutically active molecules. The book covers aspects related to genomic

Drug Discovery and Development

Drug Discovery and Development
  • Author : Ramarao Poduri
  • Publisher : Springer Nature
  • Release : 21 January 2022
GET THIS BOOKDrug Discovery and Development

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable

Artificial Intelligence in Drug Discovery

Artificial Intelligence in Drug Discovery
  • Author : Nathan Brown
  • Publisher : Royal Society of Chemistry
  • Release : 11 November 2020
GET THIS BOOKArtificial Intelligence in Drug Discovery

Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and

Prostate Cancer

Prostate Cancer
  • Author : Philippe E. Spiess
  • Publisher : IntechOpen
  • Release : 25 November 2011
GET THIS BOOKProstate Cancer

The present textbook highlights many of the exciting discoveries made in the diagnosis and treatment of prostate cancer over the past decade. International thought leaders have contributed to this effort providing a comprehensive and state-of-the art review of the signaling pathways and genetic alterations essential in prostate cancer. This work provides an essential resource for healthcare professionals and scientists dedicated to this field. This textbook is dedicated to the efforts and advances made by our scientific community, realizing we have

Peptide-based Drug Discovery

Peptide-based Drug Discovery
  • Author : Ved Srivastava
  • Publisher : Royal Society of Chemistry
  • Release : 26 June 2017
GET THIS BOOKPeptide-based Drug Discovery

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes

Drug Discovery and Development

Drug Discovery and Development
  • Author : Vishwanath Gaitonde,Partha Karmakar,Ashit Trivedi
  • Publisher : BoD – Books on Demand
  • Release : 11 March 2020
GET THIS BOOKDrug Discovery and Development

The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains

Imaging in Drug Discovery and Early Clinical Trials

Imaging in Drug Discovery and Early Clinical Trials
  • Author : Markus Rudin
  • Publisher : Springer Science & Business Media
  • Release : 11 July 2006
GET THIS BOOKImaging in Drug Discovery and Early Clinical Trials

This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.