TDP 43 and Neurodegeneration

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

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  • Author : Vijay Kumar
  • Publisher : Academic Press
  • Pages : 270 pages
  • ISBN : 0128204400
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTDP 43 and Neurodegeneration

TDP-43 and Neurodegeneration

TDP-43 and Neurodegeneration
  • Author : Vijay Kumar,Manoj Kumar Jaiswal
  • Publisher : Academic Press
  • Release : 23 October 2021
GET THIS BOOKTDP-43 and Neurodegeneration

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells

Advanced Understanding of Neurodegenerative Diseases

Advanced Understanding of Neurodegenerative Diseases
  • Author : Raymond Chuen-Chung Chang
  • Publisher : BoD – Books on Demand
  • Release : 16 December 2011
GET THIS BOOKAdvanced Understanding of Neurodegenerative Diseases

Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of

Stem Cell Therapy for Organ Failure

Stem Cell Therapy for Organ Failure
  • Author : Indumathi Somasundaram
  • Publisher : Springer
  • Release : 02 January 2015
GET THIS BOOKStem Cell Therapy for Organ Failure

The book “STEM CELL THERAPY FOR ORGAN FAILURES” edited by Dr. S. Indumathi demonstrates the In Vitro and In vivo therapeutic strategies and applications of pre- and post-natal stem cells for treating the failures of various organ systems of our body in a wide perspective. It explores the past, present and the futuristic approach of the exciting field of stem cells and its intriguing properties involved in tissue repair and regeneration. The prime focus of this volume is to unravel

RNA Metabolism in Neurodegenerative Diseases

RNA Metabolism in Neurodegenerative Diseases
  • Author : Rita Sattler,Christopher J. Donnelly
  • Publisher : Springer
  • Release : 18 June 2018
GET THIS BOOKRNA Metabolism in Neurodegenerative Diseases

It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to

Spectrums of Amyotrophic Lateral Sclerosis

Spectrums of Amyotrophic Lateral Sclerosis
  • Author : Christopher A. Shaw,Jessia R. Morrice
  • Publisher : John Wiley & Sons
  • Release : 04 May 2021
GET THIS BOOKSpectrums of Amyotrophic Lateral Sclerosis

SPECTRUMS OF AMYOTROPHIC LATERAL SCLEROSIS Discover state-of-the-art research findings on ALS from leading authors and editors in the field In Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies. In the book, readers

Neurodegeneration

Neurodegeneration
  • Author : Dennis Dickson,Roy O. Weller
  • Publisher : John Wiley & Sons
  • Release : 09 September 2011
GET THIS BOOKNeurodegeneration

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within

Geriatric Neurology

Geriatric Neurology
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 18 December 2019
GET THIS BOOKGeriatric Neurology

Geriatric Neurology, Volume 167, serves as an update on the basic biological and behavioral mechanisms underlying the aging process, with an emphasis on neurological aging and state-of-the-art reviews on our understanding of vascular, cognitive, neurodegenerative and neuropsychiatric diseases in the elderly. Developed with an eye to providing both the basic underpinnings of age-related changes and the clinical information necessary to aid in diagnostics and treatment, the book serves as a useful volume for students, basic and translational scientists, and practicing clinicians

Pathobiology of Human Disease

Pathobiology of Human Disease
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 01 August 2014
GET THIS BOOKPathobiology of Human Disease

Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a

Palliative Care in Amyotrophic Lateral Sclerosis

Palliative Care in Amyotrophic Lateral Sclerosis
  • Author : David Oliver,Gian Domenico Borasio,Wendy Johnston
  • Publisher : Oxford University Press, USA
  • Release : 21 January 2022
GET THIS BOOKPalliative Care in Amyotrophic Lateral Sclerosis

Amytrophic Lateral Sclerosis (ALS or motor neurone disease) is a progressive neurodegenerative disease that can cause profound suffering for both the patient and their family. Whilst new treatments for ALS are being developed, these are not curative and offer only the potential to slow its progression. Palliative care must therefore be integral to the clinical approach to the disease. Palliative Care in Amyotrophic Lateral Sclerosis: From diagnosis to bereavement reflects the wide scope of this care; it must cover not

Mechanisms of Secondary Brain Damage

Mechanisms of Secondary Brain Damage
  • Author : A. Baethmann,K. G. Go,A. Unterberg
  • Publisher : Springer Science & Business Media
  • Release : 09 March 2013
GET THIS BOOKMechanisms of Secondary Brain Damage

A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent

Diagnosis of Neurogenetic Disorders: Contribution of Next Generation Sequencing and Deep Phenotyping

Diagnosis of Neurogenetic Disorders: Contribution of Next Generation Sequencing and Deep Phenotyping
  • Author : Alisdair McNeill
  • Publisher : MDPI
  • Release : 23 October 2019
GET THIS BOOKDiagnosis of Neurogenetic Disorders: Contribution of Next Generation Sequencing and Deep Phenotyping

The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain. Correctly classifying the pathogenicity of genomic variants from amongst the large number of variants identified by next-generation sequencing is recognized as

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
  • Author : Robert Vink,Mihai Nechifor
  • Publisher : University of Adelaide Press
  • Release : 21 January 2022
GET THIS BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the

Pathology, Prevention and Therapeutics of Neurodegenerative Disease

Pathology, Prevention and Therapeutics of Neurodegenerative Disease
  • Author : Sarika Singh,Neeraj Joshi
  • Publisher : Springer
  • Release : 24 September 2018
GET THIS BOOKPathology, Prevention and Therapeutics of Neurodegenerative Disease

This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases

Neuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer's Disease
  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release : 30 December 2016
GET THIS BOOKNeuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is