The Chemistry and Biology of Nitroxyl HNO

The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research Provides a valuable coverage of HNO’s chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule Contains high quality content from recognized experts in both industry and academia

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  • Author : Fabio Doctorovich
  • Publisher : Elsevier
  • Pages : 424 pages
  • ISBN : 0128011645
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Chemistry and Biology of Nitroxyl HNO

The Chemistry and Biology of Nitroxyl (HNO)

The Chemistry and Biology of Nitroxyl (HNO)
  • Author : Fabio Doctorovich,Patrick J. Farmer,Marcelo A. Marti
  • Publisher : Elsevier
  • Release : 01 September 2016
GET THIS BOOKThe Chemistry and Biology of Nitroxyl (HNO)

The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of

Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor

Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor
  • Author : Mark Wesley Campbell
  • Publisher : Unknown Publisher
  • Release : 20 September 2021
GET THIS BOOKSynthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor

Nitroxyl (HNO) is a biologically relevant small molecule with considerable clinical promise for the treatment of heart failure. However, studies of the chemistry and biology of nitroxyl are hampered by its instability in aqueous solution. To aid in biological and chemical studies, nitroxyl donors (molecules that degrade to release HNO) have been synthesized which utilize a 3-hydroxy-2-naphthyl methyl (HNM) OH protecting group. Our group0́9s focus is on the synthesis of nitroxyl donors that rapidly release HNO under physiological

NOx Related Chemistry

NOx Related Chemistry
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 January 2015
GET THIS BOOKNOx Related Chemistry

NOx Related Chemistry is a volume of a series that presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced. Best-qualified scientists write on their own recent results dealing with basic fundamentals of NO-chemistry,

Enzymology and Molecular Biology of Carbonyl Metabolism 4

Enzymology and Molecular Biology of Carbonyl Metabolism 4
  • Author : Henry Weiner,David W. Crabb,T. Geoffrey Flynn
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKEnzymology and Molecular Biology of Carbonyl Metabolism 4

The Sixth International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism was held outside of Dublin, Ireland at the end of June, 1992. Prof. Keith Tipton, Chairman of the Biochemistry Department at Trinity College, kindly agreed to host the meeting. On behalf of all of us who attended I wish to extend our sincere thanks to the whole Tipton family for making us feel so welcome in Ireland. It has been a decade since the frrst workshop was held

Mechanistic Studies on the Reactions of Vitamin B12 Complexes with the Nitroxyl (HNO) Donors Angeli's Salt and Piloty's Acid

Mechanistic Studies on the Reactions of Vitamin B12 Complexes with the Nitroxyl (HNO) Donors Angeli's Salt and Piloty's Acid
  • Author : Harishchandra Subedi
  • Publisher : Unknown Publisher
  • Release : 20 September 2021
GET THIS BOOKMechanistic Studies on the Reactions of Vitamin B12 Complexes with the Nitroxyl (HNO) Donors Angeli's Salt and Piloty's Acid

Nitric oxide (NO, 0́NO), the `1992 Molecule of the Year', is a gaseous messenger molecule produced in cells from L-arginine by nitric oxide synthases. The chemical and biological properties of NO have been extensively studied for well over a decade. However, recent studies have shown that nitroxyl (nitrosyl hydride, HNO), the one-electron-reduction product of NO, may also be formed in biological systems, from nitric oxide synthase-catalyzed oxidation of L-arginine in the absence of tetrahydrobiopterin and by enzyme catalyzed reduction of NO.

Nitrosation Reactions and the Chemistry of Nitric Oxide

Nitrosation Reactions and the Chemistry of Nitric Oxide
  • Author : D.L.H. Williams
  • Publisher : Elsevier
  • Release : 16 December 2004
GET THIS BOOKNitrosation Reactions and the Chemistry of Nitric Oxide

Since 1988, there has been much literature published on the chemistry of nitric oxide, particularly in the field of S-nitrosation and the chemistry of S-nitroso compounds. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown until

Chemical and Biochemical Physics, Kinetics and Thermodynamics

Chemical and Biochemical Physics, Kinetics and Thermodynamics
  • Author : Gennadiĭ Efremovich Zaikov
  • Publisher : Nova Publishers
  • Release : 20 September 2021
GET THIS BOOKChemical and Biochemical Physics, Kinetics and Thermodynamics

This book includes new and important research on antioxidants for chemistry and biology, kinetics and mechanisms of molecular, radical and ion reactions in chemistry and biochemistry, chemistry of ozone (reactions of ozone with organic and inorganic compounds, action of antiozonants), application of electron magnetic resonance and nuclear magnetic resonance in chemistry and biology, investigations of the structure and properties of nanocomposites (nanotubes, particularly), investigations on the structure and properties of nanocomposites (nanotubes, particularly), investigations of heterogeneous-heterophases mechanisms of reaction in

Electron Spin Interactions in Chemistry and Biology

Electron Spin Interactions in Chemistry and Biology
  • Author : Gertz Likhtenshtein
  • Publisher : Springer
  • Release : 25 July 2016
GET THIS BOOKElectron Spin Interactions in Chemistry and Biology

This book presents the versatile and pivotal role of electron spin interactions in nature. It provides the background, methodologies and tools for basic areas related to spin interactions, such as spin chemistry and biology, electron transfer, light energy conversion, photochemistry, radical reactions, magneto-chemistry and magneto-biology. The book also includes an overview of designing advanced magnetic materials, optical and spintronic devices and photo catalysts. This monograph will be of interest to scientists and graduate students working in the areas related to

Free Radicals in Chemistry and Biology

Free Radicals in Chemistry and Biology
  • Author : Milan Lazar
  • Publisher : CRC Press
  • Release : 31 March 1989
GET THIS BOOKFree Radicals in Chemistry and Biology

Elementary radical reactions are described in terms of fundamental knowledge of organic chemistry and chemical physics in this valuable reference text. The complex radical processes of nonchain and chain mechanisms, such as dimerization, alkylation, polymerization, telomerization, halogenation pyrolysis, oxidation and combustion, are complemented by reactions in chemical lasers and in the cosmos, as well as by reactions in biological objects under normal or pathological metabolism. The text also provides the synthesis of facts from various fields of research and involves

Oxidation and Antioxidants in Organic Chemistry and Biology

Oxidation and Antioxidants in Organic Chemistry and Biology
  • Author : Evgeny T. Denisov,Igor B. Afanas'ev
  • Publisher : CRC Press
  • Release : 29 March 2005
GET THIS BOOKOxidation and Antioxidants in Organic Chemistry and Biology

Providing a comprehensive review of reactions of oxidation for different classes of organic compounds and polymers, and biological processes mediated by free radicals, Oxidation and Antioxidants in Organic Chemistry and Biology puts the data and bibliographical information you need into one easy-to-use resource. You will find up-to-date information about mechanisms of action of antioxidants, their reactivity, reactions of intermediates, synergism, and antioxidants with cyclic mechanism action. Supplying useful, quantitative data in tables that make the information easy to find, the

Advances in Hydrogen Sulfide Biology

Advances in Hydrogen Sulfide Biology
  • Author : Yi-Chun Zhu
  • Publisher : Springer Nature
  • Release : 24 July 2021
GET THIS BOOKAdvances in Hydrogen Sulfide Biology

Hydrogen sulfide (H2S) has emerged as an important gas signalling molecule in a series of organs/tissues, on the diseases of which it plays protective roles, such as proangiogenic effects in ischemic tissues, antiapoptotic effects in the cardiomyocytes, regularization of fatal arrhythmia in myocardial infarction, amelioration of inflammation in autoimmune diseases, modification of neuronal transmission, increase in sodium excretion from the kidney, and amelioration of insulin resistance, etc. This book focuses on the effect of hydrogen sulfide in cardiovascular

Issues in Chemistry and General Chemical Research: 2011 Edition

Issues in Chemistry and General Chemical Research: 2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 09 January 2012
GET THIS BOOKIssues in Chemistry and General Chemical Research: 2011 Edition

Issues in Chemistry and General Chemical Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chemistry and General Chemical Research. The editors have built Issues in Chemistry and General Chemical Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chemistry and General Chemical Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of

Quantum Mechanical/Molecular Mechanical Approaches for the Investigation of Chemical Systems – Recent Developments and Advanced Applications

Quantum Mechanical/Molecular Mechanical Approaches for the Investigation of Chemical Systems – Recent Developments and Advanced Applications
  • Author : Thomas S. Hofer,Sam P. de Visser
  • Publisher : Frontiers Media SA
  • Release : 28 November 2018
GET THIS BOOKQuantum Mechanical/Molecular Mechanical Approaches for the Investigation of Chemical Systems – Recent Developments and Advanced Applications

The QM/MM method, short for quantum mechanical/molecular mechanical, is a highly versatile approach for the study of chemical phenomena, combining the accuracy of quantum chemistry to describe the region of interest with the efficiency of molecular mechanical potentials to represent the remaining part of the system. Originally conceived in the 1970s by the influential work of the the Nobel laureates Martin Karplus, Michael Levitt and Arieh Warshel, QM/MM techniques have evolved into one of the most accurate

Reactive Species Detection in Biology

Reactive Species Detection in Biology
  • Author : Frederick A. Villamena
  • Publisher : Elsevier
  • Release : 23 October 2016
GET THIS BOOKReactive Species Detection in Biology

Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis,

Solar-Energy-Absorbing Substances and Oxidative Stress and Inflammatory Diseases

Solar-Energy-Absorbing Substances and Oxidative Stress and Inflammatory Diseases
  • Author : George Sosnovsky,C. Thomas Gnewuch,Mikołaj Jawdosiuk
  • Publisher : Cambridge Scholars Publishing
  • Release : 23 June 2017
GET THIS BOOKSolar-Energy-Absorbing Substances and Oxidative Stress and Inflammatory Diseases

This book explores various topics relevant to understanding the complexities of biological effects generated by solar radiation. Solar-energy-absorbing substances are evaluated, including sunscreen agents, and their influence on cancers and diseases. One assumption is the use of sunscreen agents cannot prevent the photoinitiation of biological system malfunction, such as immunosuppression. On the contrary, sunscreens can help enhance the negative solar-energy-induced effects, such as by skin penetration. This collection offers critical appraisals of clinical studies involving vitamins and nonsteroidal anti-inflammatory agents