The Chemistry and Biology of Nitroxyl HNO

The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research Provides a valuable coverage of HNO’s chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule Contains high quality content from recognized experts in both industry and academia

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  • Author : Fabio Doctorovich
  • Publisher : Elsevier
  • Pages : 424 pages
  • ISBN : 0128011645
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Chemistry and Biology of Nitroxyl HNO

The Chemistry and Biology of Nitroxyl (HNO)

The Chemistry and Biology of Nitroxyl (HNO)
  • Author : Fabio Doctorovich,Patrick J. Farmer,Marcelo A. Marti
  • Publisher : Elsevier
  • Release : 01 September 2016
GET THIS BOOKThe Chemistry and Biology of Nitroxyl (HNO)

The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of

Gasotransmitters in Plants

Gasotransmitters in Plants
  • Author : Lorenzo Lamattina,Carlos García-Mata
  • Publisher : Springer
  • Release : 01 September 2016
GET THIS BOOKGasotransmitters in Plants

This book describes the three gasotransmitters nitric oxide (NO), hydrogen sulphide (H2S) and carbon monoxide (CO) and their function as intracellular signalling molecules in plants. Common properties are shared by NO, H2S and CO: they are beneficial at low concentrations but hazardous in higher amounts; they are small molecules of gas; they can freely cross cell membranes; their effects do not rely on receptors; they are generated enzymatically and their production is regulated; their functions can be mimicked

NOx Related Chemistry

NOx Related Chemistry
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 January 2015
GET THIS BOOKNOx Related Chemistry

NOx Related Chemistry is a volume of a series that presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced. Best-qualified scientists write on their own recent results dealing with basic fundamentals of NO-chemistry,

The Chemical Biology of Nitrogen

The Chemical Biology of Nitrogen
  • Author : Christopher T Walsh
  • Publisher : Royal Society of Chemistry
  • Release : 21 May 2021
GET THIS BOOKThe Chemical Biology of Nitrogen

From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. The Chemical Biology of Nitrogen comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. This book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen

Free Radicals in Chemistry and Biology

Free Radicals in Chemistry and Biology
  • Author : Milan Lazar
  • Publisher : CRC Press
  • Release : 31 March 1989
GET THIS BOOKFree Radicals in Chemistry and Biology

Elementary radical reactions are described in terms of fundamental knowledge of organic chemistry and chemical physics in this valuable reference text. The complex radical processes of nonchain and chain mechanisms, such as dimerization, alkylation, polymerization, telomerization, halogenation pyrolysis, oxidation and combustion, are complemented by reactions in chemical lasers and in the cosmos, as well as by reactions in biological objects under normal or pathological metabolism. The text also provides the synthesis of facts from various fields of research and involves

Bioactive Spin Labels

Bioactive Spin Labels
  • Author : Renat I. Zhdanov
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKBioactive Spin Labels

Bioactive Spin Labels is a collection of contributions by leading experts on nitroxyl radicals and their application in biomedicine. These compounds are used as side specific contrast agents for in-vivo EPR techniques. Their potential as drugs is investigated. Bioactive Spin Labels is a must for researchers in bioorganic chemistry, pharmacology and biomedicine.

Nitric Oxide

Nitric Oxide
  • Author : Louis J. Ignarro,Bruce Freeman
  • Publisher : Academic Press
  • Release : 03 August 2017
GET THIS BOOKNitric Oxide

Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs. With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid

Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor

Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor
  • Author : Mark Wesley Campbell
  • Publisher : Unknown Publisher
  • Release : 24 January 2022
GET THIS BOOKSynthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor

Nitroxyl (HNO) is a biologically relevant small molecule with considerable clinical promise for the treatment of heart failure. However, studies of the chemistry and biology of nitroxyl are hampered by its instability in aqueous solution. To aid in biological and chemical studies, nitroxyl donors (molecules that degrade to release HNO) have been synthesized which utilize a 3-hydroxy-2-naphthyl methyl (HNM) OH protecting group. Our group0́9s focus is on the synthesis of nitroxyl donors that rapidly release HNO under physiological

Nitrogen Oxides—Advances in Research and Application: 2013 Edition

Nitrogen Oxides—Advances in Research and Application: 2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 21 June 2013
GET THIS BOOKNitrogen Oxides—Advances in Research and Application: 2013 Edition

Nitrogen Oxides—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Nitrogen Dioxide. The editors have built Nitrogen Oxides—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nitrogen Dioxide in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nitrogen Oxides—Advances in Research and

Solar-Energy-Absorbing Substances and Oxidative Stress and Inflammatory Diseases

Solar-Energy-Absorbing Substances and Oxidative Stress and Inflammatory Diseases
  • Author : George Sosnovsky,C. Thomas Gnewuch,Mikołaj Jawdosiuk
  • Publisher : Cambridge Scholars Publishing
  • Release : 23 June 2017
GET THIS BOOKSolar-Energy-Absorbing Substances and Oxidative Stress and Inflammatory Diseases

This book explores various topics relevant to understanding the complexities of biological effects generated by solar radiation. Solar-energy-absorbing substances are evaluated, including sunscreen agents, and their influence on cancers and diseases. One assumption is the use of sunscreen agents cannot prevent the photoinitiation of biological system malfunction, such as immunosuppression. On the contrary, sunscreens can help enhance the negative solar-energy-induced effects, such as by skin penetration. This collection offers critical appraisals of clinical studies involving vitamins and nonsteroidal anti-inflammatory agents

Measurement of Antioxidant Activity and Capacity

Measurement of Antioxidant Activity and Capacity
  • Author : Resat Apak,Esra Capanoglu,Fereidoon Shahidi
  • Publisher : John Wiley & Sons
  • Release : 20 February 2018
GET THIS BOOKMeasurement of Antioxidant Activity and Capacity

A comprehensive reference for assessing the antioxidant potential of foods and essential techniques for developing healthy food products Measurement of Antioxidant Activity and Capacity offers a much-needed resource for assessing the antioxidant potential of food and includes proven approaches for creating healthy food products. With contributions from world-class experts in the field, the text presents the general mechanisms underlying the various assessments, the types of molecules detected, and the key advantages and disadvantages of each method. Both thermodynamic (i.e.

Reactive Species Detection in Biology

Reactive Species Detection in Biology
  • Author : Frederick A. Villamena
  • Publisher : Elsevier
  • Release : 23 October 2016
GET THIS BOOKReactive Species Detection in Biology

Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis,

Nitroxides

Nitroxides
  • Author : Didier Gigmes,Olivier Ouari
  • Publisher : Royal Society of Chemistry
  • Release : 14 May 2021
GET THIS BOOKNitroxides

This book covers synthesis, physicochemical studies and applications of nitroxides, showcasing the developments which have occurred in recent years.

Endothelial Dysfunction and Inflammation

Endothelial Dysfunction and Inflammation
  • Author : Shauna Dauphinee,Aly Karsan
  • Publisher : Springer Science & Business Media
  • Release : 24 September 2010
GET THIS BOOKEndothelial Dysfunction and Inflammation

Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in