The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

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  • Author : Cheryl S Rosenfeld
  • Publisher : Academic Press
  • Pages : 560 pages
  • ISBN : 0128016728
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease
  • Author : Cheryl S Rosenfeld
  • Publisher : Academic Press
  • Release : 10 October 2015
GET THIS BOOKThe Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological

Developmental Origins of Health and Disease

Developmental Origins of Health and Disease
  • Author : Peter Gluckman,Mark Hanson
  • Publisher : Cambridge University Press
  • Release : 20 April 2006
GET THIS BOOKDevelopmental Origins of Health and Disease

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these

Epigenetic Epidemiology

Epigenetic Epidemiology
  • Author : Karin B. Michels
  • Publisher : Springer Science & Business Media
  • Release : 02 January 2012
GET THIS BOOKEpigenetic Epidemiology

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease
  • Author : Randy L Jirtle,Frederick L. Tyson
  • Publisher : Springer Science & Business Media
  • Release : 16 May 2013
GET THIS BOOKEnvironmental Epigenomics in Health and Disease

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics
  • Author : Michael D. Waters,Claude L. Hughes
  • Publisher : John Wiley & Sons
  • Release : 04 January 2018
GET THIS BOOKTranslational Toxicology and Therapeutics

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Epigenetics in Human Disease

Epigenetics in Human Disease
  • Author : Trygve O. Tollefsbol
  • Publisher : Academic Press
  • Release : 21 January 2021
GET THIS BOOKEpigenetics in Human Disease

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable,

Evolutionary Thinking in Medicine

Evolutionary Thinking in Medicine
  • Author : Alexandra Alvergne,Crispin Jenkinson,Charlotte Faurie
  • Publisher : Springer
  • Release : 13 May 2016
GET THIS BOOKEvolutionary Thinking in Medicine

The aim of this edited book is to provide health professionals, across a wide variety of specialisms, with a targeted access to evolutionary medicine. Throughout the book, the views of both medical and evolutionary scientists on the latest relevant research is presented with a focus on practical implications. The inclusion of boxes explaining the theoretical background as well as both a glossary for technical terms and a lay summary for non- specialists enable medical researchers, public health professionals, policy makers,

Environmental Epigenetics

Environmental Epigenetics
  • Author : L. Joseph Su,Tung-chin Chiang
  • Publisher : Springer
  • Release : 18 May 2015
GET THIS BOOKEnvironmental Epigenetics

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended

Developmental Origins of Health and Disease (DOHaD)

Developmental Origins of Health and Disease (DOHaD)
  • Author : Takeo Kubota,Hideoki Fukuoka
  • Publisher : Springer
  • Release : 28 June 2018
GET THIS BOOKDevelopmental Origins of Health and Disease (DOHaD)

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early

Transgenerational Epigenetics

Transgenerational Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Elsevier
  • Release : 02 May 2014
GET THIS BOOKTransgenerational Epigenetics

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms

Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease

Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease
  • Author : Fumihiro Sata,Hideoki Fukuoka,Mark Hanson
  • Publisher : Springer
  • Release : 11 December 2018
GET THIS BOOKPre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease

This book reviews public health activities such as awareness campaigns, health education, and strategies for health policy based on recent epidemiological studies that provide insights into epigenetic processes caused by environmental factors and developmental plasticity. It provides the latest concepts and findings on the public health aspects of Developmental Origins of Health and Disease (DOHaD) research regarding early prevention of non-communicable diseases (NCDs). Attention is especially paid to key issues, including strategies for the effective prevention of NCDs in developmental

Nutrition, Epigenetics and Health

Nutrition, Epigenetics and Health
  • Author : Burdge Graham,Lillycrop Karen
  • Publisher : World Scientific
  • Release : 07 October 2016
GET THIS BOOKNutrition, Epigenetics and Health

Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be

Nutritional Epigenomics

Nutritional Epigenomics
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 20 July 2019
GET THIS BOOKNutritional Epigenomics

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity,

Neuroendocrine Regulation of Animal Vocalization

Neuroendocrine Regulation of Animal Vocalization
  • Author : Cheryl S. Rosenfeld,Frauke Hoffmann
  • Publisher : Academic Press
  • Release : 04 December 2020
GET THIS BOOKNeuroendocrine Regulation of Animal Vocalization

Neuroendocrine Regulation of Animal Vocalization: Mechanisms and Anthropogenic Factors in Animal Communication examines the underpinning neuroendocrine (NE) mechanisms that drive animal communication across taxa. Written by international subject experts, the book focuses on the importance of animal communication in survival and reproduction at an individual and species level, and the impact that increased production and accumulation of endocrine-disrupting chemicals (EDCs) can have on these regulatory processes. This book discusses sound production, perception, processing, and response across a range of animals.

Epigenetics

Epigenetics
  • Author : Benedikt Hallgrimsson Ph.D.,Brian K. Hall Ph.D.
  • Publisher : Univ of California Press
  • Release : 11 April 2011
GET THIS BOOKEpigenetics

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in