The Orexin Hypocretin System

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

Produk Detail:

  • Author : Seiji Nishino
  • Publisher : Springer Science & Business Media
  • Pages : 416 pages
  • ISBN : 1592599508
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Orexin Hypocretin System

The Orexin/Hypocretin System

The Orexin/Hypocretin System
  • Author : Seiji Nishino,Takeshi Sakurai
  • Publisher : Springer Science & Business Media
  • Release : 22 November 2007
GET THIS BOOKThe Orexin/Hypocretin System

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness

The Orexin/Hypocretin System

The Orexin/Hypocretin System
  • Author : Jim R. Fadel,Joshua A. Burk
  • Publisher : Academic Press
  • Release : 03 January 2019
GET THIS BOOKThe Orexin/Hypocretin System

The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists. Provides an overview of new research on

Hypocretins

Hypocretins
  • Author : Luis De Lecea,J. Gregor Sutcliffe
  • Publisher : Springer Science & Business Media
  • Release : 25 April 2007
GET THIS BOOKHypocretins

The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred

The Orexin System. Basic Science and Role in Sleep Pathology

The Orexin System. Basic Science and Role in Sleep Pathology
  • Author : M.A. Steiner,M. Yanagisawa,M. Clozel
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 28 May 2021
GET THIS BOOKThe Orexin System. Basic Science and Role in Sleep Pathology

The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep

The Orexin/hypocretin System

The Orexin/hypocretin System
  • Author : Anantha Shekhar
  • Publisher : Elsevier
  • Release : 18 October 2021
GET THIS BOOKThe Orexin/hypocretin System

"In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological

Behavioral Neuroscience of Orexin/Hypocretin

Behavioral Neuroscience of Orexin/Hypocretin
  • Author : Andrew J Lawrence,Luis de Lecea
  • Publisher : Springer
  • Release : 29 May 2017
GET THIS BOOKBehavioral Neuroscience of Orexin/Hypocretin

This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal states, critical for higher order functioning. From a clinical

Orexin and Sleep

Orexin and Sleep
  • Author : Takeshi Sakurai,S.R. Pandi-Perumal,Jaime M. Monti
  • Publisher : Springer
  • Release : 22 September 2015
GET THIS BOOKOrexin and Sleep

This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology

The Genetic Basis of Sleep and Sleep Disorders

The Genetic Basis of Sleep and Sleep Disorders
  • Author : Paul Shaw,Mehdi Tafti,Michael J. Thorpy
  • Publisher : Cambridge University Press
  • Release : 24 October 2013
GET THIS BOOKThe Genetic Basis of Sleep and Sleep Disorders

The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter

Sleep Hormones

Sleep Hormones
  • Author : Gerald Litwack
  • Publisher : Academic Press
  • Release : 18 October 2021
GET THIS BOOKSleep Hormones

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and

Narcolepsy

Narcolepsy
  • Author : Christian R. Baumann,Claudio L. Bassetti,Thomas E. Scammell
  • Publisher : Springer Science & Business Media
  • Release : 01 July 2011
GET THIS BOOKNarcolepsy

The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder

Neuroimaging of Sleep and Sleep Disorders

Neuroimaging of Sleep and Sleep Disorders
  • Author : Eric Nofzinger,Pierre Maquet,Michael J. Thorpy
  • Publisher : Cambridge University Press
  • Release : 07 March 2013
GET THIS BOOKNeuroimaging of Sleep and Sleep Disorders

An up-to-date, superbly illustrated practical guide to the effective use of neuroimaging in the patient with sleep disorders. The only book to date to provide comprehensive coverage of this topic. A must for all healthcare workers interested in understanding the causes, consequences and treatment of sleep disorders.

Hypothalamus in Health and Diseases

Hypothalamus in Health and Diseases
  • Author : Stavros Baloyannis,Jan Gordeladze
  • Publisher : BoD – Books on Demand
  • Release : 05 December 2018
GET THIS BOOKHypothalamus in Health and Diseases

The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement