The Organic Chemistry of Drug Design and Drug Action

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

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  • Author : Richard B. Silverman
  • Publisher : Elsevier
  • Pages : 422 pages
  • ISBN : 0080571239
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Richard B. Silverman
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKThe Organic Chemistry of Drug Design and Drug Action

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Richard B. Silverman
  • Publisher : Elsevier
  • Release : 02 December 2012
GET THIS BOOKThe Organic Chemistry of Drug Design and Drug Action

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Richard B. Silverman
  • Publisher : Academic Press
  • Release : 26 January 2004
GET THIS BOOKThe Organic Chemistry of Drug Design and Drug Action

Standard medicinal texts are organized by classes of drugs with an emphasis on descriptions of their pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalized drug action and allows the reader to extrapolate to many related classed of drug molecules.

Chemistry and Molecular Aspects of Drug Design and Action

Chemistry and Molecular Aspects of Drug Design and Action
  • Author : E. A. Rekka,P. N. Kourounakis
  • Publisher : CRC Press
  • Release : 28 April 2008
GET THIS BOOKChemistry and Molecular Aspects of Drug Design and Action

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to deve

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Richard B. Silverman,Mark W. Holladay
  • Publisher : Academic Press
  • Release : 29 March 2014
GET THIS BOOKThe Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach

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  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release : 23 November 2019
GET THIS BOOKSmall Molecule Drug Discovery

Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The

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  • Author : Jie Jack Li,E. J. Corey
  • Publisher : John Wiley & Sons
  • Release : 03 April 2013
GET THIS BOOKDrug Discovery

Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection,

Strategies for Organic Drug Synthesis and Design

Strategies for Organic Drug Synthesis and Design
  • Author : Daniel Lednicer
  • Publisher : John Wiley & Sons
  • Release : 04 March 2009
GET THIS BOOKStrategies for Organic Drug Synthesis and Design

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and

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The Practice of Medicinal Chemistry
  • Author : Camille Georges Wermuth,David Aldous,Pierre Raboisson,Didier Rognan
  • Publisher : Elsevier
  • Release : 01 July 2015
GET THIS BOOKThe Practice of Medicinal Chemistry

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to

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Drug Design
  • Author : Gerhard Klebe
  • Publisher : Springer
  • Release : 10 July 2013
GET THIS BOOKDrug Design

Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples

The Organic Chemistry of Drug Synthesis

The Organic Chemistry of Drug Synthesis
  • Author : Daniel Lednicer
  • Publisher : John Wiley & Sons
  • Release : 21 November 1994
GET THIS BOOKThe Organic Chemistry of Drug Synthesis

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also

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  • Author : Joaquín M. Campos Rosa,M. Encarnación Camacho Quesada
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 21 August 2017
GET THIS BOOKDrug Design and Action

This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents.

Pharmacokinetics and Metabolism in Drug Design

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  • Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
  • Publisher : John Wiley & Sons
  • Release : 01 May 2006
GET THIS BOOKPharmacokinetics and Metabolism in Drug Design

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything

Medicinal Chemistry of Anticancer Drugs

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  • Author : Carmen Avendano,J. Carlos Menendez
  • Publisher : Elsevier
  • Release : 11 June 2015
GET THIS BOOKMedicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a