The Protective Arm of the Renin Angiotensin System RAS

The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

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  • Author : Thomas Unger
  • Publisher : Academic Press
  • Pages : 316 pages
  • ISBN : 0128014857
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Protective Arm of the Renin Angiotensin System RAS

The Protective Arm of the Renin Angiotensin System (RAS)

The Protective Arm of the Renin Angiotensin System (RAS)
  • Author : Thomas Unger,U. Muscha Steckelings,Robson Augusto Souza dos Santos
  • Publisher : Academic Press
  • Release : 18 April 2015
GET THIS BOOKThe Protective Arm of the Renin Angiotensin System (RAS)

The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin

Selected Chapters from the Renin-Angiotensin System

Selected Chapters from the Renin-Angiotensin System
  • Author : Aleksandar Kibel
  • Publisher : BoD – Books on Demand
  • Release : 19 August 2020
GET THIS BOOKSelected Chapters from the Renin-Angiotensin System

Selected Chapters from the Renin-Angiotensin System aims to provide a comprehensive overview of the most important physiological and pathophysiological roles of the renin-angiotensin system (RAS). The complex and convoluted RAS has been investigated for many years and, through rigorous scientific research, many important and previously unknown components and functions of the RAS have come to light. These discoveries have been crucial in the understanding of this system and provide a basis for effective modulation of the system as part of

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  • Author : Yaqian Duan
  • Publisher : Unknown Publisher
  • Release : 14 August 2022
GET THIS BOOKLoss of the Protective Arm of Renin-angiotensin-system Results in Hematopoietic Stem

Angiotensin-converting enzyme 2 (ACE2) is the primary enzyme of the vasoprotective axis of the renin-angiotensin system (RAS). We tested the hypothesis that the protective arm of the RAS axis can i) act to maintain homeostasis in the diabetic bone marrow stem cell compartment, ii) regulate the reparative function of the hematopoietic stem/progenitor cells (HSPCs) and iii) modulate the gut microbiota composition. All processes could influence the development of diabetic retinopathy. Diabetic ACE2 knockout (KO)/C57BL/6-Ins2WT/C96Y (

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  • Author : Giuseppe Mancia,Guido Grassi,Konstantinos Tsioufis,Anna Dominiczak,Enrico Agabiti Rosei
  • Publisher : CRC Press
  • Release : 06 June 2019
GET THIS BOOKManual of Hypertension of the European Society of Hypertension, Third Edition

The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological,

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  • Publisher : BoD – Books on Demand
  • Release : 25 September 2019
GET THIS BOOKAldosterone-Mineralocorticoid Receptor

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16

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  • Publisher : Humana Press
  • Release : 13 May 2017
GET THIS BOOKThe Renin-Angiotensin-Aldosterone System

This volume discusses protocols that aid in measuring different components in the renin-angiotensin-aldosterone system (RAAS). The book also looks at the methods used to assess angiotensin peptides and discerning the influence of RAAS components on different mammalian diseases. The chapters cover topics such as the use of fluorescent substrate to measure ACE2 activity in the mouse abdominal aorta, blood pressure monitoring using the radio telemetry method, and the analysis of angiotensin metabolism in the kidney using mass spectrometry. Written in

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  • Publisher : Royal Society of Chemistry
  • Release : 27 April 2022
GET THIS BOOKThe Coronavirus Pandemic and the Future

This first volume chronicles the early stages of the outbreak and world-wide spread of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures. Documenting the epidemiologic response from China, the clinical evaluation, pathology and intial therapeutics that were available during the first 6 months and onwards of the outbreak, this book records how the response to the pandemic was mounted and how various branches of science and research combined to rapidly expand our understanding of the

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  • Publisher : Springer Nature
  • Release : 02 July 2021
GET THIS BOOKTargeting Cellular Signalling Pathways in Lung Diseases

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and

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  • Publisher : Springer
  • Release : 06 December 2018
GET THIS BOOKPrehypertension and Cardiometabolic Syndrome

This book sheds new light on the management of patients with borderline cardiovascular risk factors in order to prevent their progression to end organ damage. The book stimulates discussion of this poorly understood condition and lays the groundwork for developing recommendations and guidelines. While the diagnostic and therapeutic approach to full-blown diabetes, hypertension, dyslipidemia and obesity is well defined, there is still a lack of clear understanding and guidelines as far as patients with borderline conditions – especially when multiple – are

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  • Author : Robson Augusto Souza Santos
  • Publisher : Springer Nature
  • Release : 21 August 2019
GET THIS BOOKAngiotensin-(1-7)

This is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of angiotensin-(1-7) and its receptor Mas, comprising the historical background, enzymatic pathways for generation, functions, integrative aspects of its protective profile, and its therapeutic potential. It also encompasses a comprehensive presentation of current knowledge about its widespread biological

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  • Publisher : Springer Nature
  • Release : 13 August 2021
GET THIS BOOKCOVID-19

This book highlights the overview of the COVID-19 pandemic from both the scientific and the social perspectives. The scientific part presents key facts of COVID-19, including the structure of the virus and the techniques for the diagnosis, treatment, and vaccine development against the disease, covering state-of-the-art findings and achievements worldwide. The social part is written by WHO professionals who worked on the frontier of the fight against the disease. It covers the global security situation during the pandemic, the WHO

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  • Publisher : Academic Press
  • Release : 10 October 2015
GET THIS BOOKThe Epigenome and Developmental Origins of Health and Disease

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  • Publisher : Academic Press
  • Release : 12 January 2009
GET THIS BOOKTextbook of Nephro-Endocrinology

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a