Therapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

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  • Author : William R Strohl
  • Publisher : Elsevier
  • Pages : 696 pages
  • ISBN : 1908818093
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTherapeutic Antibody Engineering

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : William R Strohl,Lila M Strohl
  • Publisher : Elsevier
  • Release : 16 October 2012
GET THIS BOOKTherapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : W. R. Strohl,Lila M. Strohl
  • Publisher : Woodhead Pub Limited
  • Release : 28 October 2021
GET THIS BOOKTherapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
  • Author : Stefan Dübel,Janice M. Reichert
  • Publisher : John Wiley & Sons
  • Release : 03 December 2014
GET THIS BOOKHandbook of Therapeutic Antibodies

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
  • Author : Zhiqiang An
  • Publisher : John Wiley & Sons
  • Release : 20 September 2011
GET THIS BOOKTherapeutic Monoclonal Antibodies

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Diagnostic and Therapeutic Antibodies

Diagnostic and Therapeutic Antibodies
  • Author : Andrew J. T. George,Catherine E. Urch
  • Publisher : Springer Science & Business Media
  • Release : 28 October 2021
GET THIS BOOKDiagnostic and Therapeutic Antibodies

Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the "magic bullet" that would allow the specific destruction of neoplastic cells. H- ever, many years' effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science

Introduction to Antibody Engineering

Introduction to Antibody Engineering
  • Author : Florian Rüker,Gordana Wozniak-Knopp
  • Publisher : Springer Nature
  • Release : 04 January 2021
GET THIS BOOKIntroduction to Antibody Engineering

This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering”

Antibody Engineering

Antibody Engineering
  • Author : Thomas Böldicke
  • Publisher : BoD – Books on Demand
  • Release : 21 February 2018
GET THIS BOOKAntibody Engineering

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by

Antibody Fc:

Antibody Fc:
  • Author : Margaret Ackerman,Falk Nimmerjahn
  • Publisher : Academic Press
  • Release : 06 August 2013
GET THIS BOOKAntibody Fc:

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of

Applications And Engineering Of Monoclonal Antibodies

Applications And Engineering Of Monoclonal Antibodies
  • Author : David J. King
  • Publisher : CRC Press
  • Release : 27 November 1998
GET THIS BOOKApplications And Engineering Of Monoclonal Antibodies

A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and a case study approach illustrates how antibodies are finding increasing use in the diagnosis and treatment of disease. The volume ends with commercial expression, purification and large-scale manufacture of antibodies

Therapeutic Antibodies

Therapeutic Antibodies
  • Author : Antony S. Dimitrov
  • Publisher : Humana Press
  • Release : 25 November 2014
GET THIS BOOKTherapeutic Antibodies

Over 2000 years ago in China, antibodies elicited by early forms of vaccination likely played a major role in the protection of the population from infectious agents. Vac- nation has been further developed in Europe and described by Edward Jenner in the late-eighteenth century, then successfully implemented worldwide. The idea to use theactiveingredientinthebloodofvaccinated(orimmunized)animalsorhumansfor the treatment of diseases came a century later. It was made possible by a series of discoveries,suchastherealizationthattheserumfromanimalsimmunizedwithtoxins, for example, diphtheria toxin or viruses, is an

Antibody Engineering

Antibody Engineering
  • Author : Carl A. K. Borrebaeck
  • Publisher : Breakthroughs in Molecular Biology
  • Release : 28 October 1995
GET THIS BOOKAntibody Engineering

This book will help researchers understand and develop designer antibodies. It is a practical `how-to' overview using state-of-the-art technologies, of antibody engineering for the production of recombinant human or mouse monoclonal antibodies. Subjects such as antibody structure relevant to antibody engineering, plant and mammalian expression vectors and hosts, recombinatorial DNA libraries, PCR cloning of single cells, engineering of affinity and biologicaleffector functions, are thoroughly dealt with by some of the leading experts in each field.

Antibody Engineering

Antibody Engineering
  • Author : Roland E. Kontermann,Stefan Dübel
  • Publisher : Springer Science & Business Media
  • Release : 10 March 2010
GET THIS BOOKAntibody Engineering

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody

Antibody Engineering

Antibody Engineering
  • Author : Benny K. C. Lo
  • Publisher : Humana Press
  • Release : 28 October 2010
GET THIS BOOKAntibody Engineering

The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to

Antibody Engineering

Antibody Engineering
  • Author : J. Donald Capra
  • Publisher : Karger Publishers
  • Release : 28 October 1997
GET THIS BOOKAntibody Engineering

The last decade has witnessed remarkable developments in antibody research and its therapeutic applications. With the methods of molecular biology it is now possible to manipulate the specificities and activities of antibody molecules to generate an almost limitless array of structures for both basic investigations and the clinical setting. The contributions to this volume cover all three domains of the antibody: the variable regions, the relatively neglected but crucial hinge, and the constant region. These studies provide critical structural and