Therapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

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  • Author : William R Strohl
  • Publisher : Elsevier
  • Pages : 696 pages
  • ISBN : 1908818093
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTherapeutic Antibody Engineering

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : William R Strohl,Lila M Strohl
  • Publisher : Elsevier
  • Release : 16 October 2012
GET THIS BOOKTherapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental

Therapeutic Antibody Engineering: Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

Therapeutic Antibody Engineering: Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry
  • Author : William R. Strohl,Lila M. Strohl
  • Publisher : Woodhead Publishing
  • Release : 13 November 2017
GET THIS BOOKTherapeutic Antibody Engineering: Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : W. R. Strohl,Lila M. Strohl
  • Publisher : Woodhead Pub Limited
  • Release : 25 July 2021
GET THIS BOOKTherapeutic Antibody Engineering

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
  • Author : Stefan Dübel,Janice M. Reichert
  • Publisher : John Wiley & Sons
  • Release : 03 December 2014
GET THIS BOOKHandbook of Therapeutic Antibodies

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
  • Author : Zhiqiang An
  • Publisher : John Wiley & Sons
  • Release : 20 September 2011
GET THIS BOOKTherapeutic Monoclonal Antibodies

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Antibody Engineering

Antibody Engineering
  • Author : Thomas Böldicke
  • Publisher : BoD – Books on Demand
  • Release : 21 February 2018
GET THIS BOOKAntibody Engineering

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by

Antibody Engineering

Antibody Engineering
  • Author : Carl A. K. Borrebaeck
  • Publisher : Breakthroughs in Molecular Biology
  • Release : 25 July 1995
GET THIS BOOKAntibody Engineering

In presenting a practical overview of the engineering of recombinant human or mouse monoclonal antibodies, the book incisively addresses essential topics such as antibody structure relevant to engineering, recombinatorial cDNA libraries, phage display, synthetic and humanized antibodies, engineering of affinity and biological effector functions, and plant, mammalian, and bacterial expression vectors and hosts. Antibody Engineering, Second Edition - written by leading experts and now thoroughly updated - is a unique resource for current information on the subject.

Diagnostic and Therapeutic Antibodies

Diagnostic and Therapeutic Antibodies
  • Author : Andrew J. T. George,Catherine E. Urch
  • Publisher : Springer Science & Business Media
  • Release : 25 July 2021
GET THIS BOOKDiagnostic and Therapeutic Antibodies

Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the "magic bullet" that would allow the specific destruction of neoplastic cells. H- ever, many years' effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science

Interleukin Twelve

Interleukin Twelve
  • Author : Luciano Adorini
  • Publisher : Karger Publishers
  • Release : 25 July 1997
GET THIS BOOKInterleukin Twelve

The contributions collected in this volume represent the most recent findings, reviewed by leading scientists in the field, on several different aspects of IL-12 biology. The opening chapter analyzes the molecular regulation of IL-12 production and its immunomodulatory activities. This is followed by three contributions describing the structure of the IL-12 receptor and its role in determining the early events in the differentiation of T cell subsets. The modulation of IL-12 activities by other cytokines such as TGF-Beta, IFN-Gamma and

Antibody Engineering

Antibody Engineering
  • Author : Roland E. Kontermann,Stefan Dübel
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKAntibody Engineering

Interest in recombinant antibody technologies has rapidly increased because of its wide range of possible applications in therapy, diagnosis, and especially, cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has facilitated the development of antibody engineering technologies. This manual presents a comprehensive collection of detailed step-by-step protocols, provided by experts. The text covers all basic methods needed in antibody engineering as well as recently developed and emerging technologies.

Antibody Engineering

Antibody Engineering
  • Author : Roland E. Kontermann,Stefan Dübel
  • Publisher : Springer Science & Business Media
  • Release : 10 March 2010
GET THIS BOOKAntibody Engineering

Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody

Antibody Engineering

Antibody Engineering
  • Author : Patrick Chames
  • Publisher : Humana Press
  • Release : 23 August 2016
GET THIS BOOKAntibody Engineering

More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is predicted to continue well into the future. Notwithstanding the many achievements already made in the field, there is still a lot of room for improvements for these molecules in terms

Therapeutic Antibodies

Therapeutic Antibodies
  • Author : Antony S. Dimitrov
  • Publisher : Humana Press
  • Release : 25 November 2014
GET THIS BOOKTherapeutic Antibodies

Over 2000 years ago in China, antibodies elicited by early forms of vaccination likely played a major role in the protection of the population from infectious agents. Vac- nation has been further developed in Europe and described by Edward Jenner in the late-eighteenth century, then successfully implemented worldwide. The idea to use theactiveingredientinthebloodofvaccinated(orimmunized)animalsorhumansfor the treatment of diseases came a century later. It was made possible by a series of discoveries,suchastherealizationthattheserumfromanimalsimmunizedwithtoxins, for example, diphtheria toxin or viruses, is an

Antibody Fc:

Antibody Fc:
  • Author : Margaret Ackerman,Falk Nimmerjahn
  • Publisher : Academic Press
  • Release : 06 August 2013
GET THIS BOOKAntibody Fc:

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of