Therapeutic Applications of Quadruplex Nucleic Acids

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligandsand the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas. "

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  • Author : Cancer Research Campaign Biomolecular Structure Unit Stephen Neidle
  • Publisher : Academic Press
  • Pages : 208 pages
  • ISBN : 9780128103722
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTherapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Cancer Research Campaign Biomolecular Structure Unit Stephen Neidle,Stephen Neidle
  • Publisher : Academic Press
  • Release : 02 September 2016
GET THIS BOOKTherapeutic Applications of Quadruplex Nucleic Acids

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligandsand the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic

Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release : 25 July 2021
GET THIS BOOKTherapeutic Applications of Quadruplex Nucleic Acids

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science

Quadruplex Nucleic Acids

Quadruplex Nucleic Acids
  • Author : Stephen Neidle,Shankar Balasubramanian
  • Publisher : Royal Society of Chemistry
  • Release : 31 October 2007
GET THIS BOOKQuadruplex Nucleic Acids

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the

Medicinal Chemistry of Nucleic Acids

Medicinal Chemistry of Nucleic Acids
  • Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
  • Publisher : John Wiley & Sons
  • Release : 10 August 2011
GET THIS BOOKMedicinal Chemistry of Nucleic Acids

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
  • Author : Loutfy H. Madkour
  • Publisher : Academic Press
  • Release : 27 August 2019
GET THIS BOOKNucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various

Biomedical Applications of Acridines

Biomedical Applications of Acridines
  • Author : Jan Ježek,Jan Hlaváček,Jaroslav Šebestík
  • Publisher : Springer
  • Release : 15 August 2017
GET THIS BOOKBiomedical Applications of Acridines

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins,

Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids
  • Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
  • Publisher : Springer Science & Business
  • Release : 22 April 2014
GET THIS BOOKChemical Biology of Nucleic Acids

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap

Interplay Between Metal Ions and Nucleic Acids

Interplay Between Metal Ions and Nucleic Acids
  • Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
  • Publisher : Springer Science & Business Media
  • Release : 02 January 2012
GET THIS BOOKInterplay Between Metal Ions and Nucleic Acids

An overview of metal ion-nucleic acid interactions, the characterisation of which is covered in solution and in the solid state. It concentrates on modern developments, including topics ranging from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs).

G-quadruplex and Microorganisms

G-quadruplex and Microorganisms
  • Author : Sara N. Richter
  • Publisher : MDPI
  • Release : 19 August 2019
GET THIS BOOKG-quadruplex and Microorganisms

G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (

Innovations in Biomolecular Modeling and Simulations

Innovations in Biomolecular Modeling and Simulations
  • Author : Tamar Schlick
  • Publisher : Royal Society of Chemistry
  • Release : 25 July 2021
GET THIS BOOKInnovations in Biomolecular Modeling and Simulations

The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This

Medicinal Chemistry Approaches to Personalized Medicine

Medicinal Chemistry Approaches to Personalized Medicine
  • Author : Karen Lackey,Bruce Roth
  • Publisher : John Wiley & Sons
  • Release : 22 November 2013
GET THIS BOOKMedicinal Chemistry Approaches to Personalized Medicine

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas,

Advances in Bionanomaterials II

Advances in Bionanomaterials II
  • Author : Stefano Piotto,Simona Concilio,Lucia Sessa,Federico Rossi
  • Publisher : Springer Nature
  • Release : 29 May 2020
GET THIS BOOKAdvances in Bionanomaterials II

This book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods for modeling the mechanical, physical, and biological properties of biomaterials. The book gathers the proceedings of the 3rd International Conference on Bio and Nanomaterials, held on September 29–October 3, 2019, on an

DNA Nanotechnology

DNA Nanotechnology
  • Author : Chunhai Fan,Yonggang Ke
  • Publisher : Springer Nature
  • Release : 07 September 2020
GET THIS BOOKDNA Nanotechnology

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific

The Alkali Metal Ions: Their Role for Life

The Alkali Metal Ions: Their Role for Life
  • Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
  • Publisher : Springer
  • Release : 09 February 2016
GET THIS BOOKThe Alkali Metal Ions: Their Role for Life

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements

G-Quadruplex Nucleic Acids

G-Quadruplex Nucleic Acids
  • Author : Danzhou Yang,Clement Lin
  • Publisher : Humana
  • Release : 07 September 2020
GET THIS BOOKG-Quadruplex Nucleic Acids

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding