Therapeutic Applications of Quadruplex Nucleic Acids

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research.

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  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Pages : 196 pages
  • ISBN : 0123751381
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTherapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids
  • Author : Stephen Neidle
  • Publisher : Academic Press
  • Release : 28 October 2021
GET THIS BOOKTherapeutic Applications of Quadruplex Nucleic Acids

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science

Biomedical Applications of Acridines

Biomedical Applications of Acridines
  • Author : Jan Ježek,Jan Hlaváček,Jaroslav Šebestík
  • Publisher : Springer
  • Release : 15 August 2017
GET THIS BOOKBiomedical Applications of Acridines

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins,

Interplay Between Metal Ions and Nucleic Acids

Interplay Between Metal Ions and Nucleic Acids
  • Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
  • Publisher : Springer Science & Business Media
  • Release : 02 January 2012
GET THIS BOOKInterplay Between Metal Ions and Nucleic Acids

An overview of metal ion-nucleic acid interactions, the characterisation of which is covered in solution and in the solid state. It concentrates on modern developments, including topics ranging from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs).

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
  • Author : Loutfy H. Madkour
  • Publisher : Academic Press
  • Release : 27 August 2019
GET THIS BOOKNucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various

G-quadruplex and Microorganisms

G-quadruplex and Microorganisms
  • Author : Sara N. Richter
  • Publisher : MDPI
  • Release : 19 August 2019
GET THIS BOOKG-quadruplex and Microorganisms

G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (

Innovations in Biomolecular Modeling and Simulations

Innovations in Biomolecular Modeling and Simulations
  • Author : Tamar Schlick
  • Publisher : Royal Society of Chemistry
  • Release : 28 October 2021
GET THIS BOOKInnovations in Biomolecular Modeling and Simulations

The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This

Medicinal Chemistry Approaches to Personalized Medicine

Medicinal Chemistry Approaches to Personalized Medicine
  • Author : Karen Lackey,Bruce Roth
  • Publisher : John Wiley & Sons
  • Release : 22 November 2013
GET THIS BOOKMedicinal Chemistry Approaches to Personalized Medicine

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues. Numerous case studies from the first generation of "personalized drugs" are presented, highlighting the challenges and opportunities for pharmaceutical development. While the majority of these examples are taken from the field of cancer treatment, other key emerging areas,

Advances in Bionanomaterials II

Advances in Bionanomaterials II
  • Author : Stefano Piotto,Simona Concilio,Lucia Sessa,Federico Rossi
  • Publisher : Springer Nature
  • Release : 29 May 2020
GET THIS BOOKAdvances in Bionanomaterials II

This book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods for modeling the mechanical, physical, and biological properties of biomaterials. The book gathers the proceedings of the 3rd International Conference on Bio and Nanomaterials, held on September 29–October 3, 2019, on an

Quadruplex Nucleic Acids

Quadruplex Nucleic Acids
  • Author : Stephen Neidle,Shankar Balasubramanian
  • Publisher : Royal Society of Chemistry
  • Release : 31 October 2007
GET THIS BOOKQuadruplex Nucleic Acids

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the

Medicinal Chemistry of Nucleic Acids

Medicinal Chemistry of Nucleic Acids
  • Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
  • Publisher : John Wiley & Sons
  • Release : 10 August 2011
GET THIS BOOKMedicinal Chemistry of Nucleic Acids

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such

The Alkali Metal Ions: Their Role for Life

The Alkali Metal Ions: Their Role for Life
  • Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
  • Publisher : Springer
  • Release : 09 February 2016
GET THIS BOOKThe Alkali Metal Ions: Their Role for Life

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements

Application of Computational Techniques in Pharmacy and Medicine

Application of Computational Techniques in Pharmacy and Medicine
  • Author : Leonid Gorb,Victor Kuz'min,Eugene Muratov
  • Publisher : Springer
  • Release : 07 November 2014
GET THIS BOOKApplication of Computational Techniques in Pharmacy and Medicine

The proposed volume provides both fundamental and detailed information about the computational and computational-experimental studies which improve our knowledge of how leaving matter functions, the different properties of drugs (including the calculation and the design of new ones), and the creation of completely new ways of treating numerical diseases. Whenever it is possible, the interplay between theory and experiment is provided. The book features computational techniques such as quantum-chemical and molecular dynamic approaches and quantitative structure–activity relationships. The initial

Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids
  • Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
  • Publisher : Springer Science & Business
  • Release : 22 April 2014
GET THIS BOOKChemical Biology of Nucleic Acids

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap

Guanine Quartets

Guanine Quartets
  • Author : Wolfgang Fritzsche,Lea Spindler
  • Publisher : Royal Society of Chemistry
  • Release : 28 October 2021
GET THIS BOOKGuanine Quartets

Guanosine and its derivatives have a high potential for self-recognition and self-assembly, as well as the recognition ability for other biologically important molecules. This book explores in detail these properties with the goal of increasing knowledge of the basic principles of guanosine-assembly, synthesis of new optimised materials and exploration of their electronic and optical properties. Following the work of COST Action MP0802, the aim is to design novel reproducible and well ordered supramolecular structures to serve as molecular-scale architectures for