Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation

Produk Detail:

  • Author : Takehiko Nohmi
  • Publisher : Academic Press
  • Pages : 224 pages
  • ISBN : 0128018038
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens
  • Author : Takehiko Nohmi,Shoji Fukushima
  • Publisher : Academic Press
  • Release : 20 May 2016
GET THIS BOOKThresholds of Genotoxic Carcinogens

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold

The Cellular Response to the Genotoxic Insult

The Cellular Response to the Genotoxic Insult
  • Author : Helmut Greim,Richard Albertini
  • Publisher : Royal Society of Chemistry
  • Release : 09 November 2015
GET THIS BOOKThe Cellular Response to the Genotoxic Insult

Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens,

Cancer Risk Assessment

Cancer Risk Assessment
  • Author : Ching-Hung Hsu,Todd Stedeford
  • Publisher : John Wiley & Sons
  • Release : 08 December 2010
GET THIS BOOKCancer Risk Assessment

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release : 16 May 2020
GET THIS BOOKInformation Resources in Toxicology

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world

Toxicological Risk Assessment of Chemicals

Toxicological Risk Assessment of Chemicals
  • Author : Elsa Nielsen,Grete Ostergaard,John Christian Larsen
  • Publisher : CRC Press
  • Release : 21 February 2008
GET THIS BOOKToxicological Risk Assessment of Chemicals

Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk assessment of chemical substances. It illustrates each step in the process: hazard identification, a dose response assessment, and exposure assessment. The book also summarizes the basic concepts of interaction of chemicals

Metal Ions in Toxicology

Metal Ions in Toxicology
  • Author : Astrid Sigel,Helmut Sigel
  • Publisher : Royal Society of Chemistry
  • Release : 19 October 2021
GET THIS BOOKMetal Ions in Toxicology

It is an old wisdom that metals are indispensable for life. Indeed, severalof them, like sodium, potassium, and calcium, are easily discovered in livingmatter. However, the role of metals and their impact on life remainedlargely hidden until inorganic chemistry and coordination chemistryexperienced a pronounced revival in the 1950s. The experimental and theoreticaltools created in this period and their application to biochemicalproblems led to the development of the field or discipline now known asBioinorganic Chemistry, Inorganic Biochemistry, or more recently alsooften

Validation of Alternative Methods for Toxicity Testing

Validation of Alternative Methods for Toxicity Testing
  • Author : Chantra Eskes,Maurice Whelan
  • Publisher : Springer
  • Release : 26 September 2016
GET THIS BOOKValidation of Alternative Methods for Toxicity Testing

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are

Hayes' Principles and Methods of Toxicology, Sixth Edition

Hayes' Principles and Methods of Toxicology, Sixth Edition
  • Author : A. Wallace Hayes,Claire L. Kruger
  • Publisher : CRC Press
  • Release : 10 October 2014
GET THIS BOOKHayes' Principles and Methods of Toxicology, Sixth Edition

Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms

Metal Ions in Toxicology: Effects, Interactions, Interdependencies

Metal Ions in Toxicology: Effects, Interactions, Interdependencies
  • Author : Astrid Sigel,Helmut Sigel,Roland K.O. Sigel
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 24 July 2015
GET THIS BOOKMetal Ions in Toxicology: Effects, Interactions, Interdependencies

Volume 8, solely devoted to the toxicology of metals and metalloids as well as their compounds, focuses on human health. Not surprisingly, all related research areas are rapidly developing due to the role of metals and metalloids in the environment, for the work place, for food and water supply, etc. Written by 40 internationally recognized experts, the 14 stimulating chapters provide an authoritative and timely resource for scientists working in the wide range from analytical, physical, inorganic, and environmental biochemistry all the way

Practical Toxicology

Practical Toxicology
  • Author : David Woolley,Adam Woolley
  • Publisher : CRC Press
  • Release : 16 March 2017
GET THIS BOOKPractical Toxicology

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the

Genetic Toxicology

Genetic Toxicology
  • Author : Albert P. Li,Robert H. Heflich
  • Publisher : CRC Press
  • Release : 27 March 1991
GET THIS BOOKGenetic Toxicology

Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and

Quantitative Risk Assessment for Environmental and Occupational Health

Quantitative Risk Assessment for Environmental and Occupational Health
  • Author : William H. Hallenbeck
  • Publisher : CRC Press
  • Release : 09 June 1993
GET THIS BOOKQuantitative Risk Assessment for Environmental and Occupational Health

Quantitative Risk Assessment for Environmental and Occupational Health, Second Edition features twice as many risk analysis models with complete examples as the previous edition. The book features new information in the following areas: Calculation of human dose rate and dose from experimental studies (animal and human) Quantitation of response Tests of significance Calculation of excess risk Calculation of confidence limits on excess risk Individual and group excess risk Conversion of risk factor units Acceptable concentrations Quantitative Risk Assessment for Environmental

A Guide to Practical Toxicology

A Guide to Practical Toxicology
  • Author : David Woolley,Adam Woolley
  • Publisher : CRC Press
  • Release : 20 February 2003
GET THIS BOOKA Guide to Practical Toxicology

Toxicology is a means to an important end: safety. The effective toxicologist begins with this in mind, and uses a clear understanding of safety as a relative concept, together with a rational view of the current safety evaluation paradigm to direct their work. Too often this approach is ignored or discouraged by traditional practice. This lucid, readable book encourages both experienced toxicologists and those in training to place toxicological investigation in such a framework. It looks at the importance of