Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds

The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

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  • Author : Shinsuke Inuki
  • Publisher : Springer Science & Business Media
  • Pages : 106 pages
  • ISBN : 9784431540434
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTotal Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
  • Author : Shinsuke Inuki
  • Publisher : Springer Science & Business Media
  • Release : 23 November 2011
GET THIS BOOKTotal Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings

Total Synthesis of Bioactive Natural Products

Total Synthesis of Bioactive Natural Products
  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release : 27 April 2019
GET THIS BOOKTotal Synthesis of Bioactive Natural Products

Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear

Total Synthesis of Natural Products

Total Synthesis of Natural Products
  • Author : Jie Jack Li,E.J. Corey
  • Publisher : Springer Science & Business Media
  • Release : 14 March 2013
GET THIS BOOKTotal Synthesis of Natural Products

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced

Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products

Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 19 October 2021
GET THIS BOOKEnantioselective Total Synthesis Of Diverse, Bioactive Natural Products

Natural product synthesis is one of the most creative branch of chemistry in terms of its boundless scope for innovation and has stimulated several generations of synthetic organic chemists. With advancement in the technology, particularly in the isolation and purification techniques, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, even to those complex molecules, which are

Multicomponent Reactions

Multicomponent Reactions
  • Author : K.L. Ameta, Ph.D.,Anshu Dandia
  • Publisher : CRC Press
  • Release : 20 September 2017
GET THIS BOOKMulticomponent Reactions

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation

Heterocycles in Natural Product Synthesis

Heterocycles in Natural Product Synthesis
  • Author : Krishna C. Majumdar,Shital K. Chattopadhyay
  • Publisher : John Wiley & Sons
  • Release : 15 June 2011
GET THIS BOOKHeterocycles in Natural Product Synthesis

Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references.

Bioactive Natural Products

Bioactive Natural Products
  • Author : Goutam Brahmachari
  • Publisher : World Scientific
  • Release : 19 October 2021
GET THIS BOOKBioactive Natural Products

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for