Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

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  • Author : Tahira Farooqui
  • Publisher : Academic Press
  • Pages : 432 pages
  • ISBN : 0128036168
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTrace Amines and Neurological Disorders

Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release : 12 July 2016
GET THIS BOOKTrace Amines and Neurological Disorders

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is

Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
  • Author : Tahira Farooqui
  • Publisher : Academic Press
  • Release : 08 August 2016
GET THIS BOOKTrace Amines and Neurological Disorders

"Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors" explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is

Chemosensory Transduction

Chemosensory Transduction
  • Author : Frank Zufall,Steven D. Munger
  • Publisher : Academic Press
  • Release : 18 February 2016
GET THIS BOOKChemosensory Transduction

Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such

The Combinatorial Index

The Combinatorial Index
  • Author : Barry A. Bunin
  • Publisher : Elsevier
  • Release : 15 April 1998
GET THIS BOOKThe Combinatorial Index

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which

Neurobiology of the Trace Amines

Neurobiology of the Trace Amines
  • Author : Alan A. Boulton,Glen B. Baker,William G. Dewhurst,Merton Sandler
  • Publisher : Springer Science & Business Media
  • Release : 12 March 2013
GET THIS BOOKNeurobiology of the Trace Amines

Many of the trace amines-more correctly called biogenic amines have been known for decades, but because of their tiny concentra tions (0. 01-100 ng/g) in brain, it was only after the development of sophisticated analytical techniques (such as mass spectrometry) that they could be identified and quantitated in nervous tissue. There are now more than 20 of them and most are related to the catecholamines and 5-hydroxytryptamine both structurally and metabolically. Their pharmacological and physiological properties make them prime candidates for

Diet and Exercise in Cognitive Function and Neurological Diseases

Diet and Exercise in Cognitive Function and Neurological Diseases
  • Author : Akhlaq A. Farooqui,Tahira Farooqui
  • Publisher : John Wiley & Sons
  • Release : 06 February 2015
GET THIS BOOKDiet and Exercise in Cognitive Function and Neurological Diseases

Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the

Biogenic Amines on Food Safety

Biogenic Amines on Food Safety
  • Author : Claudia Ruiz-Capillas,Ana Herrero Herranz
  • Publisher : MDPI
  • Release : 16 July 2019
GET THIS BOOKBiogenic Amines on Food Safety

Biogenic amines have been known for some time. These compounds are found in varying concentrations in a wide range of foods (fish, cheese, meat, wine, beer, vegetables, etc.) and their formations are influenced by different factors associated to those foods (composition, additives, ingredients, storage, microorganism, packaging, handing, conservation, etc.). The intake of foods containing high concentrations of biogenic amines can present a health hazard. Additionally, they have been used to establish indexes in various foods in order to signal the

Neurotransmitters, Drugs and Brain Function

Neurotransmitters, Drugs and Brain Function
  • Author : Roy Webster
  • Publisher : John Wiley & Sons
  • Release : 28 November 2001
GET THIS BOOKNeurotransmitters, Drugs and Brain Function

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and

Selected Topics from Neurochemistry

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  • Author : Neville N. Osborne
  • Publisher : Elsevier
  • Release : 22 October 2013
GET THIS BOOKSelected Topics from Neurochemistry

This book contains up-dated versions of articles which proved very popular when first published in Neurochemistry International. The articles draw attention to developments in a specific field perhaps unfamiliar to the reader, collating observations from a wide area which seem to point in a new direction, giving the author's personal view on a controversial topic, or directing soundly based criticism at some widely held dogma or widely used technique in the neurosciences.

Magnesium in the Central Nervous System

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  • Author : Robert Vink,Mihai Nechifor
  • Publisher : University of Adelaide Press
  • Release : 26 July 2021
GET THIS BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the

Diet and Health

Diet and Health
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
  • Publisher : National Academies Press
  • Release : 01 January 1989
GET THIS BOOKDiet and Health

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

ADHD

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  • Author : Jill M. Norvilitis
  • Publisher : BoD – Books on Demand
  • Release : 24 September 2015
GET THIS BOOKADHD

With many children and adults affected by Attention Deficit Hyperactivity Disorder, researchers strive to improve our understanding of the causes, consequences, and treatment of the disorder. This volume examines some of the broad arrays of research in the field of ADHD, from etiology to cutting-edge interventions. The 16 chapters explore topics ranging from comorbidity to advances in the search for biomarkers; to executive, cognitive, and social functioning; to the use of new and alternative therapies. Both the professional and the casual

Neuropsychopharmacology of the Trace Amines

Neuropsychopharmacology of the Trace Amines
  • Author : Alan A. Boulton,Peter R. Bieck,L. Maitre,P. Riederer
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKNeuropsychopharmacology of the Trace Amines

A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed and after their purification by physicochemical procedures that are becoming more and more efficient. The identification and quantitative analysis of minute amounts of trace amines in biological fluids or tissues

Rewire Your Brain

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  • Author : John B. Arden, PhD
  • Publisher : John Wiley & Sons
  • Release : 22 March 2010
GET THIS BOOKRewire Your Brain

How to rewire your brain to improve virtually every aspect of your life-based on the latest research in neuroscience and psychology on neuroplasticity and evidence-based practices Not long ago, it was thought that the brain you were born with was the brain you would die with, and that the brain cells you had at birth were the most you would ever possess. Your brain was thought to be “hardwired” to function in predetermined ways. It turns out that's not true.