Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

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  • Author : Tahira Farooqui
  • Publisher : Academic Press
  • Pages : 432 pages
  • ISBN : 0128036168
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTrace Amines and Neurological Disorders

Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release : 12 July 2016
GET THIS BOOKTrace Amines and Neurological Disorders

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is

The Combinatorial Index

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  • Author : Barry A. Bunin
  • Publisher : Elsevier
  • Release : 15 April 1998
GET THIS BOOKThe Combinatorial Index

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which

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  • Publisher : MDPI
  • Release : 16 July 2019
GET THIS BOOKBiogenic Amines on Food Safety

Biogenic amines have been known for some time. These compounds are found in varying concentrations in a wide range of foods (fish, cheese, meat, wine, beer, vegetables, etc.) and their formations are influenced by different factors associated to those foods (composition, additives, ingredients, storage, microorganism, packaging, handing, conservation, etc.). The intake of foods containing high concentrations of biogenic amines can present a health hazard. Additionally, they have been used to establish indexes in various foods in order to signal the

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  • Author : Robert Vink,Mihai Nechifor
  • Publisher : University of Adelaide Press
  • Release : 19 August 2022
GET THIS BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the

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  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
  • Publisher : National Academies Press
  • Release : 01 January 1989
GET THIS BOOKDiet and Health

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Neuropsychopharmacology of the Trace Amines

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  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKNeuropsychopharmacology of the Trace Amines

A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed and after their purification by physicochemical procedures that are becoming more and more efficient. The identification and quantitative analysis of minute amounts of trace amines in biological fluids or tissues

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  • Author : Abel Lajtha
  • Publisher : Springer Science & Business Media
  • Release : 18 April 2013
GET THIS BOOKChemical and Cellular Architecture

After the completion of the first edition of this series, this editor thought that a new edition would not be warranted in less than IS, perhaps 20, years, but it seems that we live in a time in which rapid changes are the norm and findings in a field such as neurochemistry develop exponentially. The task of a future editor attempting to get a comprehensive neurochemical handbook for the year 2000 would be even less enviable, but by then information processing may

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  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems
  • Publisher : National Academies Press
  • Release : 18 May 2018
GET THIS BOOKPublic Health Consequences of E-Cigarettes

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette

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  • Author : John B. Arden, PhD
  • Publisher : John Wiley & Sons
  • Release : 22 March 2010
GET THIS BOOKRewire Your Brain

How to rewire your brain to improve virtually every aspect of your life-based on the latest research in neuroscience and psychology on neuroplasticity and evidence-based practices Not long ago, it was thought that the brain you were born with was the brain you would die with, and that the brain cells you had at birth were the most you would ever possess. Your brain was thought to be “hardwired” to function in predetermined ways. It turns out that's not true.

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  • Publisher : Springer
  • Release : 28 September 2017
GET THIS BOOKCalcium Signaling: From Physiology to Diseases

This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important,

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  • Author : Frank Zufall,Steven D. Munger
  • Publisher : Academic Press
  • Release : 18 February 2016
GET THIS BOOKChemosensory Transduction

Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such

Neurotransmitters, Drugs and Brain Function

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  • Author : Roy Webster
  • Publisher : John Wiley & Sons
  • Release : 28 November 2001
GET THIS BOOKNeurotransmitters, Drugs and Brain Function

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and