Translational Neuroimaging

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

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  • Author : Robert A. McArthur
  • Publisher : Academic Press
  • Pages : 464 pages
  • ISBN : 0123869978
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTranslational Neuroimaging

Translational Neuroimaging

Translational Neuroimaging
  • Author : Robert A. McArthur
  • Publisher : Academic Press
  • Release : 05 October 2012
GET THIS BOOKTranslational Neuroimaging

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human

Translational Neuropsychopharmacology

Translational Neuropsychopharmacology
  • Author : Trevor W. Robbins,Barbara J. Sahakian
  • Publisher : Springer
  • Release : 22 September 2016
GET THIS BOOKTranslational Neuropsychopharmacology

This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to

Translational Neuroscience

Translational Neuroscience
  • Author : James E. Barrett,Joseph T. Coyle,Michael Williams
  • Publisher : Cambridge University Press
  • Release : 28 June 2012
GET THIS BOOKTranslational Neuroscience

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease

Anxiety Disorders: Advances in Research and Treatment: 2011 Edition

Anxiety Disorders: Advances in Research and Treatment: 2011 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 09 January 2012
GET THIS BOOKAnxiety Disorders: Advances in Research and Treatment: 2011 Edition

Anxiety Disorders: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Anxiety Disorders in a concise format. The editors have built Anxiety Disorders: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Anxiety Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Anxiety Disorders:

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
  • Author : Daniel Laskowitz,Gerald Grant
  • Publisher : CRC Press
  • Release : 01 December 2015
GET THIS BOOKTranslational Research in Traumatic Brain Injury

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps

The Charnoly Body

The Charnoly Body
  • Author : Sushil Sharma
  • Publisher : CRC Press
  • Release : 30 January 2019
GET THIS BOOKThe Charnoly Body

Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas,

The Neuroimaging of Brain Diseases

The Neuroimaging of Brain Diseases
  • Author : Christophe Habas
  • Publisher : Springer
  • Release : 15 June 2018
GET THIS BOOKThe Neuroimaging of Brain Diseases

Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they use. By focusing on both structure and function this book will provide a strong foundation for emerging developments in the field.

Translational Medicine

Translational Medicine
  • Author : James Mittra,Christopher-Paul Milne
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKTranslational Medicine

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science

Neuroimaging of Pain

Neuroimaging of Pain
  • Author : Luca Saba
  • Publisher : Springer
  • Release : 08 June 2017
GET THIS BOOKNeuroimaging of Pain

Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the

Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders

Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders
  • Author : Silvana Galderisi,Lynn E. DeLisi,Stefan Borgwardt
  • Publisher : Springer
  • Release : 31 January 2019
GET THIS BOOKNeuroimaging of Schizophrenia and Other Primary Psychotic Disorders

This book presents the state of the art in the use of neuroimaging technologies in the study of schizophrenia and other primary psychotic disorders. The contributions of neuroimaging in the characterization of these disorders are reviewed across diagnoses, by focusing on psychopathological domains and at-risk populations in order to understand the implications for treatment. The principal neuroimaging findings are described in detail, identifying those that are common to and specific for each disorder and highlighting important pitfalls. Attention is drawn

Neuroimaging Genetics

Neuroimaging Genetics
  • Author : Kristin L. Bigos,Ahmad R. Hariri,Daniel R. Weinberger
  • Publisher : Oxford University Press
  • Release : 16 February 2016
GET THIS BOOKNeuroimaging Genetics

The field of neuroimaging genetics has grown exponentially over the past decade. To date there are more than 10,000 published papers involving MRI, PET, MEG and genetics. Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics. The work presented in this volume elaborates on the explosive interest from diverse research

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development
  • Author : George G. Nomikos,Douglas E. Feltner
  • Publisher : Academic Press
  • Release : 18 June 2019
GET THIS BOOKTranslational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to

Identifying Neuroimaging-Based Markers for Distinguishing Brain Disorders

Identifying Neuroimaging-Based Markers for Distinguishing Brain Disorders
  • Author : Yuhui Du,Jing Sui,Dongdong Lin
  • Publisher : Frontiers Media SA
  • Release : 10 July 2020
GET THIS BOOKIdentifying Neuroimaging-Based Markers for Distinguishing Brain Disorders

There has been increasing interests in exploring biomarkers from brain images, aiming to have a better understanding and a more effective diagnosis of brain disorders such as schizophrenia, bipolar disorder, schizoaffective disorder, autism spectrum disorder, attention-deficit/hyperactivity disorder, Alzheimer’s disease and so on. Therefore, it is important to identify disease-specific changes for distinguishing healthy controls and patients with brain disorders as well as for differentiating patients with different disorders showing similar clinical symptoms. Biomarkers can be identified from different