Translational Systems Biology

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams

Produk Detail:

  • Author : Yoram Vodovotz
  • Publisher : Elsevier
  • Pages : 178 pages
  • ISBN : 0123978904
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKTranslational Systems Biology

Translational Systems Biology

Translational Systems Biology
  • Author : Yoram Vodovotz,Gary An
  • Publisher : Elsevier
  • Release : 08 October 2014
GET THIS BOOKTranslational Systems Biology

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine
  • Author : Qing Yan
  • Publisher : Academic Press
  • Release : 18 April 2017
GET THIS BOOKTranslational Bioinformatics and Systems Biology Methods for Personalized Medicine

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics,

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease
  • Author : Stephen Sonis,Alessandro Villa
  • Publisher : Academic Press
  • Release : 14 September 2019
GET THIS BOOKTranslational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease

Translational Biology in Medicine

Translational Biology in Medicine
  • Author : M. Montano
  • Publisher : Elsevier
  • Release : 08 December 2014
GET THIS BOOKTranslational Biology in Medicine

The recent emphasis in biomedical research on translational biology and personalized medicine is revolutionizing conceptual and experimental approaches to understanding and improving human health. Translational Biology in Medicine begins with an introduction to experimental model systems for disease, such as cell lines, primary cells, stem cells and animal models for disease, followed by a systematic description of genetic and genomic profiling and biomarker validation currently used in biomedical research. Examples of translation studies that have used these models and methods

Handbook of Systems Biology

Handbook of Systems Biology
  • Author : Marian Walhout,Marc Vidal,Job Dekker
  • Publisher : Academic Press
  • Release : 31 December 2012
GET THIS BOOKHandbook of Systems Biology

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as

Systems Biology of Microbial Infection

Systems Biology of Microbial Infection
  • Author : Reinhard Guthke,Jörg Linde,Marc Thilo Figge,Franziska Mech
  • Publisher : Frontiers E-books
  • Release : 18 October 2021
GET THIS BOOKSystems Biology of Microbial Infection

The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data

Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly

Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 05 March 2020
GET THIS BOOKComputational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly

Computational Approaches for Understanding Dynamical Systems: Protein Folding and Assembly, Volume 170 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Pairwise-Additive and Polarizable Atomistic Force Fields for Molecular Dynamics Simulations of Proteins, Scale-consistent approach to the derivation of coarse-grained force fields for simulating structure,

Encyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology
  • Author : Anonim
  • Publisher : Elsevier
  • Release : 21 August 2018
GET THIS BOOKEncyclopedia of Bioinformatics and Computational Biology

Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for

A Systems Biology Approach to Blood

A Systems Biology Approach to Blood
  • Author : Seth Joel Corey,Marek Kimmel,Joshua N. Leonard
  • Publisher : Springer
  • Release : 06 December 2014
GET THIS BOOKA Systems Biology Approach to Blood

The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems

Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 22 March 2019
GET THIS BOOKProgress in Molecular Biology and Translational Science

Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer

An Introduction to Computational Systems Biology

An Introduction to Computational Systems Biology
  • Author : Karthik Raman
  • Publisher : CRC Press
  • Release : 30 May 2021
GET THIS BOOKAn Introduction to Computational Systems Biology

This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable

Systems Biology

Systems Biology
  • Author : Aleš Prokop,Béla Csukás
  • Publisher : Springer Science & Business Media
  • Release : 28 August 2013
GET THIS BOOKSystems Biology

Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing