TRP Channels as Therapeutic Targets

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them

Produk Detail:

  • Author : Arpad Szallasi
  • Publisher : Academic Press
  • Pages : 536 pages
  • ISBN : 0124200796
  • Rating : 5/5 from 1 reviews
CLICK HERE TO GET THIS BOOKTRP Channels as Therapeutic Targets

TRP Channels as Therapeutic Targets

TRP Channels as Therapeutic Targets
  • Author : Arpad Szallasi
  • Publisher : Academic Press
  • Release : 09 April 2015
GET THIS BOOKTRP Channels as Therapeutic Targets

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these

Neurobiology of TRP Channels

Neurobiology of TRP Channels
  • Author : Tamara Luti Rosenbaum Emir
  • Publisher : CRC Press
  • Release : 09 August 2017
GET THIS BOOKNeurobiology of TRP Channels

During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli. Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated

Ion Channels as Therapeutic Targets, Part A

Ion Channels as Therapeutic Targets, Part A
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 23 February 2016
GET THIS BOOKIon Channels as Therapeutic Targets, Part A

Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Discusses the use of ion channels as therapeutic targets Chapters are written by authorities in their

Innovative Medicine

Innovative Medicine
  • Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
  • Publisher : Springer
  • Release : 13 October 2015
GET THIS BOOKInnovative Medicine

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps

Transient Receptor Potential Channels

Transient Receptor Potential Channels
  • Author : Md. Shahidul Islam
  • Publisher : Springer Science & Business Media
  • Release : 04 February 2011
GET THIS BOOKTransient Receptor Potential Channels

Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms,

Transient Receptor Potential (TRP) Channels

Transient Receptor Potential (TRP) Channels
  • Author : Veit Flockerzi,Bernd Nilius
  • Publisher : Springer Science & Business Media
  • Release : 07 February 2007
GET THIS BOOKTransient Receptor Potential (TRP) Channels

This volume provides up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression.

Ion Channels as Therapeutic Targets

Ion Channels as Therapeutic Targets
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 31 March 2016
GET THIS BOOKIon Channels as Therapeutic Targets

This volume is the second part of the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Discusses the use of ion channels as therapeutic targets Chapters are written by

Ion Channel Drug Discovery

Ion Channel Drug Discovery
  • Author : Brian Cox,Martin Gosling
  • Publisher : Royal Society of Chemistry
  • Release : 03 September 2014
GET THIS BOOKIon Channel Drug Discovery

Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and

TRP Channels in Health and Disease

TRP Channels in Health and Disease
  • Author : Alexander Dietrich
  • Publisher : MDPI
  • Release : 25 June 2019
GET THIS BOOKTRP Channels in Health and Disease

Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with

Vanilloid Receptor TRPV1 in Drug Discovery

Vanilloid Receptor TRPV1 in Drug Discovery
  • Author : Arthur Gomtsyan,Connie R. Faltynek
  • Publisher : John Wiley & Sons
  • Release : 12 February 2010
GET THIS BOOKVanilloid Receptor TRPV1 in Drug Discovery

Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it "the holy grail" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on

Ion Channels in Health and Sickness

Ion Channels in Health and Sickness
  • Author : Fatima Shad Kaneez
  • Publisher : BoD – Books on Demand
  • Release : 10 October 2018
GET THIS BOOKIon Channels in Health and Sickness

Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book

Mammalian Transient Receptor Potential (TRP) Cation Channels

Mammalian Transient Receptor Potential (TRP) Cation Channels
  • Author : Bernd Nilius,Veit Flockerzi
  • Publisher : Springer
  • Release : 24 June 2014
GET THIS BOOKMammalian Transient Receptor Potential (TRP) Cation Channels

​In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations