Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

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  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Pages : 516 pages
  • ISBN : 0128096829
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKViral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors
  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release : 03 July 2017
GET THIS BOOKViral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the

Viral Proteases and Antiviral Protease Inhibitor Therapy

Viral Proteases and Antiviral Protease Inhibitor Therapy
  • Author : Uwe Lendeckel,Nigel M. Hooper
  • Publisher : Springer Science & Business Media
  • Release : 19 June 2009
GET THIS BOOKViral Proteases and Antiviral Protease Inhibitor Therapy

The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most

Regulatory Proteolytic Enzymes and Their Inhibitors

Regulatory Proteolytic Enzymes and Their Inhibitors
  • Author : Staffan Magnusson,Martin Ottesen,Bent Foltmann
  • Publisher : Elsevier
  • Release : 18 May 2014
GET THIS BOOKRegulatory Proteolytic Enzymes and Their Inhibitors

Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies

Antiviral Strategies

Antiviral Strategies
  • Author : Hans-Georg Kräusslich,Ralf Bartenschlager
  • Publisher : Springer Science & Business Media
  • Release : 02 December 2008
GET THIS BOOKAntiviral Strategies

A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development

Activation of Viruses by Host Proteases

Activation of Viruses by Host Proteases
  • Author : Eva Böttcher-Friebertshäuser,Wolfgang Garten,Hans Dieter Klenk
  • Publisher : Springer
  • Release : 22 May 2018
GET THIS BOOKActivation of Viruses by Host Proteases

This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in

Retroviral Proteases

Retroviral Proteases
  • Author : Lawrence C. Kuo,Jules A. Shafer
  • Publisher : Gulf Professional Publishing
  • Release : 06 October 1994
GET THIS BOOKRetroviral Proteases

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Medical Aspects of Proteases and Protease Inhibitors

Medical Aspects of Proteases and Protease Inhibitors
  • Author : Nobuhiko Katunuma,H. Kido,H. Fritz,J. Travis
  • Publisher : IOS Press
  • Release : 30 July 1997
GET THIS BOOKMedical Aspects of Proteases and Protease Inhibitors

The work presents articles on proteases and their inhibitors as mediators of biological functions. Topics addressed: cathepsin B and L; MHC and peptide interaction; procathepsin L; cysteine proteinases; selective neuronal cell death; HIV and influenza virus; tumor invasion; gingivitis; bacterial infection. Readers: professionals in the area of molecular medicine, biochemists, molecular biologists, clinical pharmacologists, pharmaceutical companies.

Proteases and Their Receptors in Inflammation

Proteases and Their Receptors in Inflammation
  • Author : Nathalie Vergnolle,Michel Chignard
  • Publisher : Springer Science & Business Media
  • Release : 03 August 2011
GET THIS BOOKProteases and Their Receptors in Inflammation

Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the

Viral Proteases and Antiviral Protease Inhibitor Therapy

Viral Proteases and Antiviral Protease Inhibitor Therapy
  • Author : Uwe Lendeckel,Nigel M. Hooper
  • Publisher : Springer
  • Release : 29 August 2009
GET THIS BOOKViral Proteases and Antiviral Protease Inhibitor Therapy

The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most

Proteases and Their Inhibitors in Cancer Metastasis

Proteases and Their Inhibitors in Cancer Metastasis
  • Author : J-M. Foidart,R.J. Muschel
  • Publisher : Springer Science & Business Media
  • Release : 30 July 2021
GET THIS BOOKProteases and Their Inhibitors in Cancer Metastasis

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as

Proteinase and Peptidase Inhibition

Proteinase and Peptidase Inhibition
  • Author : H. John Smith,Claire Simons
  • Publisher : CRC Press
  • Release : 28 March 2002
GET THIS BOOKProteinase and Peptidase Inhibition

Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the

Applications of Metal-Organic Frameworks and Their Derived Materials

Applications of Metal-Organic Frameworks and Their Derived Materials
  • Author : Inamuddin,Rajender Boddula,Mohd Imran Ahamed,Abdullah M. Asiri
  • Publisher : John Wiley & Sons
  • Release : 04 May 2020
GET THIS BOOKApplications of Metal-Organic Frameworks and Their Derived Materials

Metal–organic frameworks (MOFs) are porous crystalline polymers constructed by metal sites and organic building blocks. Since the discovery of MOFs in the 1990s, they have received tremendous research attention for various applications due to their high surface area, controllable morphology, tunable chemical properties, and multifunctionalities, including MOFs as precursors and self-sacrificing templates for synthesizing metal oxides, heteroatom-doped carbons, metal-atoms encapsulated carbons, and others. Thus, awareness and knowledge about MOFs and their derived nanomaterials with conceptual understanding are essential for